The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein. - Wikidata - awgldk - TriplyDB

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

http://www.wikidata.org/entity/Q34117600

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Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease Disease-modifying therapeutic directions for Lewy-Body dementias Impact of lysosome status on extracellular vesicle content and release A splicing mutation in VPS4B causes dentin dysplasia I.Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors.Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.Exosomal cell-to-cell transmission of alpha synuclein oligomers.Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.Rab GTPases: The Key Players in the Molecular Pathway of Parkinson's Disease.Alpha-synuclein: from secretion to dysfunction and death.α-Synuclein: the long distance runner.Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission.Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Mechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous role The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis.Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.Neuroinflammation in Synucleinopathies.Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation.The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.Exosomes in the Pathology of Neurodegenerative Diseases.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy.Up-regulation of Vps4A promotes neuronal apoptosis after intracerebral hemorrhage in adult rats.Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.The expression changes of vacuolar protein sorting 4B (VPS4B) following middle cerebral artery occlusion (MCAO) in adult rats brain hippocampus.Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.

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The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

http://www.wikidata.org/entity/Q34117600

description

2011 nî lūn-bûn

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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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Atsushi Takeda

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Emiko Miura

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Hiroyuki Arai

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P2860

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

Regulation of Vps4 during MVB sorting and cytokinesis

Membrane budding and scission by the ESCRT machinery: it's all in the neck

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Staging of brain pathology related to sporadic Parkinson's disease

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