Does PTEN loss impair DNA double-strand break repair by homologous recombination? - Wikidata - awgldk - TriplyDB

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

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DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine HER2 overexpression renders human breast cancers sensitive to PARP inhibition independently of any defect in homologous recombination DNA repair.Therapeutic applications of PARP inhibitors: anticancer therapy and beyond Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer PARP inhibitors in cancer therapy: an update.Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?Recent advances in targeting DNA repair pathways for the treatment of ovarian cancer and their clinical relevance.

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Does PTEN loss impair DNA double-strand break repair by homologous recombination?

http://www.wikidata.org/entity/Q34119182

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2011 nî lūn-bûn

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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@ast

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@en

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

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label

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@ast

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@en

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@nl

prefLabel

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@ast

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@en

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@nl

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1078-0432.CCR-11-3131

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Clinical Cancer Research

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Does PTEN loss impair DNA double-strand break repair by homologous recombination?

@en

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Arun Gupta

http://www.w3.org/2001/XMLSchema#string

Clayton R Hunt

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Nobuo Horikoshi

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Tej K Pandita

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P2860

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Essential role for nuclear PTEN in maintaining chromosomal integrity

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.

Chromatin remodeling finds its place in the DNA double-strand break response.

PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy.

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.

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920-922

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scholarly article

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10.1158/1078-0432.CCR-11-3131

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4

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4151559

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