Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. - Wikidata - awgldk - TriplyDB

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

http://www.wikidata.org/entity/Q34123406

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Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?Stress granules in the viral replication cycle Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species.Gene expression changes leading extreme alkaline tolerance in Amur ide (Leuciscus waleckii) inhabiting soda lake.Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.A novel role for Tm7sf2 gene in regulating TNFα expression Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction.Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis.IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR.The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells.LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin Anti-leukemic mechanisms of pegylated arginase I in acute lymphoblastic T-cell leukemia.Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex.Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells.eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies.Molecular signal networks and regulating mechanisms of the unfolded protein response.Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response.Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.Cell death induced by endoplasmic reticulum stress.Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells.Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors.Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells.HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence.Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.Dysregulation of mRNA translation and energy metabolism in cancer.PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly.Overexpression of Tobacco GCN2 Stimulates Multiple Physiological Changes Associated With Stress Tolerance.GCN2 controls the cellular checkpoint: potential target for regulating inflammation.

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Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

http://www.wikidata.org/entity/Q34123406

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

@ast

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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type

label

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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prefLabel

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

@ast

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

@en

Phosphorylation of eIF2α at se ...... ptation to glucose deficiency.

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MBC.E10-01-0023

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Molecular Biology of the Cell

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Phosphorylation of eIF2α at se ...... aptation to glucose deficiency

@en

P2093

Andreas I Papadakis

http://www.w3.org/2001/XMLSchema#string

Antonis E Koromilas

http://www.w3.org/2001/XMLSchema#string

Donalyn Scheuner

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Hala Muaddi

http://www.w3.org/2001/XMLSchema#string

Maria Hatzoglou

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Mithu Majumder

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Philippos Peidis

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Randal J Kaufman

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P2860

Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

Molecular interaction between HAX-1 and XIAP inhibits apoptosis

IAPs: more than just inhibitors of apoptosis proteins

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

Perk is essential for translational regulation and cell survival during the unfolded protein response

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

Glycolysis inhibition for anticancer treatment

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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3220-3231

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10.1091/MBC.E10-01-0023

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18

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21

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2010-07-21T00:00:00Z

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45365763

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20660158

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phosphorylation

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2938387

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