Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
about
Heterozygous yeast deletion collection screens reveal essential targets of Hsp90Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradationRoles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceActivation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replicationAssembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complexThe role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancerHeat shock proteins at the crossroads between cancer and Alzheimer's diseaseHuman small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an updateSynergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine ModelNovel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.Association between Hsp90 and the ClC-2 chloride channel upregulates channel functionPhase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignanciesHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateHeat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infectionHeat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytesEpidemiological and molecular mechanisms aspects linking obesity and cancer.The ATPases: a new family for a family-based drug design approach.Targeting aerobic glycolysis and HIF-1alpha expression enhance imiquimod-induced apoptosis in cancer cells.The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derruboneMolecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer.HPMA copolymers: origins, early developments, present, and future.Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinomaSublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells.Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor.mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarrayUp-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer.Thermo-targeted drug delivery of geldanamycin to hyperthermic tumor margins with diblock elastin-based biopolymers.Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.PKC epsilon is a unique regulator for hsp90 beta gene in heat shock response.Induction of HSF1 expression is associated with sporadic colorectal cancer.Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling.ATPases as drug targets: learning from their structure.Photodynamic treatment induces an apoptotic pathway involving calcium, nitric oxide, p53, p21-activated kinase 2, and c-Jun N-terminal kinase and inactivates survival signal in human umbilical vein endothelial cellsWithaferin A targets heat shock protein 90 in pancreatic cancer cells.Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
P2860
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P2860
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@ast
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@en
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@nl
type
label
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@ast
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@en
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@nl
prefLabel
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@ast
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@en
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@nl
P356
P1433
P1476
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
@en
P2093
Blagosklonny MV
P2888
P304
P356
10.1038/SJ.LEU.2402415
P577
2002-04-01T00:00:00Z
P5875
P6179
1050811432