Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model.

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model.

Item
http://www.wikidata.org/entity/Q34127547
Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityPrion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models.Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer's Disease.Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer's disease.Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina?Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
P2860

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model.

Item
http://www.wikidata.org/entity/Q34127547
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@ast
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@en
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@nl
type
label
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@ast
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@en
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@nl
prefLabel
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@ast
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@en
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Pathological Hallmarks, Clinic ...... London Transgenic Mouse Model.
@en
P2093
P2860
P304
P31
P356
P478
P50
P577
P5875
P698
P921
P932