Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs. - Wikidata - awgldk - TriplyDB

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.

http://www.wikidata.org/entity/Q34127971

about

Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Mitochondrial cytochrome c oxidase deficiency Barth Syndrome: From Mitochondrial Dysfunctions Associated with Aberrant Production of Reactive Oxygen Species to Pluripotent Stem Cell Studies A new age in functional genomics using CRISPR/Cas9 in arrayed library screening The application of CRISPR-Cas9 genome editing in Caenorhabditis elegans Mitochondrial DNA disease-molecular insights and potential routes to a cure Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing Mitochondrial DNA damage induced autophagy, cell death, and disease Toward a therapy for mitochondrial disease Mitochondrial DNA disease and developmental implications for reproductive strategies Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Comprehensive analysis of the specificity of transcription activator-like effector nucleases.Selective elimination of mitochondrial mutations in the germline by genome editing Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.International regulatory landscape and integration of corrective genome editing into in vitro fertilization.Mitochondrial DNA: impacting central and peripheral nervous systems.The use of mitochondria-targeted endonucleases to manipulate mtDNA The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.The role of mitochondrial DNA mutation on neurodegenerative diseases.Mitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Mitochondrial disease: clinical aspects, molecular mechanisms, translational science, and clinical frontiers.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Seamless editing of the chloroplast genome in plants.Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.Modifying the Mitochondrial Genome.Emerging therapies for mitochondrial disorders.Mitochondria in pluripotent stem cells: stemness regulators and disease targets.A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells.Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results.The Development of TALE Nucleases for Biotechnology.Development of pharmacological strategies for mitochondrial disorders.Expert consensus document: Mitochondrial function as a therapeutic target in heart failure Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.Mitochondrial Modification Techniques and Ethical Issues.

P2860

Q26741333-91722B51-D25F-4E7C-9E60-7077CE580F8A Q26752831-CE6ACFE1-170C-44F5-AC13-FF82D9438883 Q26769015-F149667E-BD08-40DF-89CA-7D6DB2DD58E8 Q26772690-6163B642-922C-4175-B38F-2CA3D1BD3BC4 Q26781135-55066822-8C5B-48A2-99F7-A3D7ED83D01B Q26785937-BF0016AB-C3FE-48A0-90EA-BED7812F76BE Q27005350-8F126357-C453-4565-947A-B961042C7308 Q27024089-F0DA8233-7E9B-4989-87B9-7C64182B0176 Q28072518-02296186-6526-4D18-8A9D-0B01F8154891 Q28080024-05BF5454-79F0-41E3-89BA-DCFE2778C5AC Q28649392-26E8EA4C-DBF9-4BF1-821F-6CB37E30E4E5 Q33931594-DA8DE1F6-5D43-4836-A6E4-C6EF29BD4EE1 Q34381076-D9155B90-BC94-4CD6-8F42-A46DD7D044A6 Q34406749-AD3F996A-96F7-474F-A752-BDDF34E40400 Q34473537-B2553D77-5DB3-4296-920F-E98F054251FD Q34478955-A7D6B82D-7F9F-4646-A099-DF209961C9DA Q34611496-93F55681-1EAB-4081-B506-984383F3AA49 Q34737643-278D470C-636D-4778-A996-57C1850C2F6E Q34758002-44CB9540-3E7F-4F71-B8AE-C573C4284BD5 Q34979054-5B0EB4FB-27C8-455D-AFC5-FA0FF3FFFDD8 Q35152954-5636B537-6124-4781-8E82-0F8BD864985C Q35190973-526D7DB3-FE6E-4EEA-BD78-3FDD243C3F69 Q35893619-E012F972-EE21-48BC-A309-8F5AC78727C3 Q35997215-5D1A8D71-8526-4EE9-9849-49DBD0F39B4D Q36088172-B560D00F-7DBB-4EA9-9F44-FFA62F357F96 Q36090529-478F3E2E-6F11-4A8F-948B-1E667D6A4E12 Q36444101-6337EA46-05C5-458D-AF85-595D83E11812 Q36894373-56561FCC-A26B-4F95-B677-F38A4D8D7C76 Q36967723-2AB3D18F-8751-4F05-8828-82C740421B87 Q37232271-6F02D0F6-3B41-4AAC-A386-A1ED0C7ABEF8 Q37289982-A7EEA279-BACB-4AF1-9552-8BF51749920A Q37336497-AC9B50B1-F815-490E-A363-B94A4729A8E8 Q37396906-C4EC1CF2-C945-413D-913C-62F49EB1960C Q37421594-B2B9930F-7AFB-4309-83E0-59DA944A0766 Q37618929-6BDADCAC-75DE-4D4D-843C-19AB75CC87F2 Q37652116-AF3C8065-6EF3-41FE-8E18-2CDEB86641C0 Q37686237-609F0294-22E6-4DBF-856D-76E30252EFE1 Q37699474-4C975193-A12F-4BB5-8ADB-C0F33A7D3BD5 Q37710809-51D680F1-34D8-4467-85ED-D8CFBF1DB45E Q37729935-9059CD34-4B36-40A3-9E10-128A6B74C3D1

P2860

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.

http://www.wikidata.org/entity/Q34127971

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@ast

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@en

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@nl

type

label

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@ast

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@en

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@nl

prefLabel

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@ast

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@en

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@nl

P1433

Q34127971-208AD41F-6B24-4152-9A02-40404C7C883E

P1476

Q34127971-61A423EF-4795-41ED-B03B-DAD3D0110447

P2093

Q34127971-2871B497-D059-4B53-B0F2-ACA6CE330955

Q34127971-56E1EFE6-45DA-440B-96F0-7D327B068D72

Q34127971-7D63E53F-CBAF-4FA2-B61C-74911310A89D

Q34127971-B324CEA0-9251-49E5-9FCC-F38C18B87556

Q34127971-FB8DC177-37DA-4232-B3D4-C75C84B97962

P2860

Q34127971-008EFE81-5D4D-4376-AB7E-5307A3BA3BDF

Q34127971-05C50ED3-08F4-4406-9BA7-C2D87667B0EF

Q34127971-1E897A8E-5542-4BEE-958F-4E7BD0BE28E2

Q34127971-28853DB2-23BB-49D3-911B-4049A52A4520

Q34127971-2B25FE02-3831-4FF3-8213-F9DD83D7E36B

Q34127971-2CA648CB-D47B-4A9E-AF23-01BFC1E350F5

Q34127971-3C6629DC-A688-460B-B76F-960EF27B05A8

Q34127971-5EC07679-E027-42CF-9970-D51D59FB611E

Q34127971-60CE6DC2-D23D-43A8-A756-B65908231252

Q34127971-82C8BF98-C977-4E44-ADB2-3F63230F4CB4

P2888

Q34127971-EBB98B71-4720-44C0-9FB6-8590DECC74D2

P304

Q34127971-597EA0FE-4EC7-4930-A589-74109413E620

P31

Q34127971-58C89600-83FD-474E-A68C-D82D97EB5F1C

P356

Q34127971-C8F9A9DE-A820-4A15-AC1C-01756E323977

P407

Q34127971-495F52D5-053E-449C-91B0-B9A824D2F2D9

P433

Q34127971-EBA122AA-21D0-459D-B7D3-95E71C405D7F

P478

Q34127971-00EB5BE0-C6B4-4FFA-9063-339AE2FCD81F

P577

Q34127971-B1C46054-0462-4AD1-8196-0A93F6DBD1FC

P5875

Q34127971-CE7B0E6F-823E-40DE-885B-DBDA5974E4AD

P6179

Q34127971-BD7FA570-95DD-4CDF-B2BC-F2F767455BFD

P698

Q34127971-A27A36AC-A39F-4E4E-9FAC-626E157875B2

P921

Q34127971-70834386-67B4-463A-B6BE-AFCB1C7B5208

P932

Q34127971-3C292F37-D9CF-402A-AC8F-B1EA66CE26C9

P356

P1433

Nature Medicine

P1476

Specific elimination of mutant ...... t-derived cells by mitoTALENs.

@en

P2093

Carlos T Moraes

http://www.w3.org/2001/XMLSchema#string

Milena Pinto

http://www.w3.org/2001/XMLSchema#string

Sandra R Bacman

http://www.w3.org/2001/XMLSchema#string

Siôn L Williams

http://www.w3.org/2001/XMLSchema#string

Susana Peralta

http://www.w3.org/2001/XMLSchema#string

P2860

Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control.

A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

Genetic engineering of human pluripotent cells using TALE nucleases

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

What regulates mitochondrial DNA copy number in animal cells?

The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle.

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease.

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

Quantitation and analysis of the formation of HO-endonuclease stimulated chromosomal translocations by single-strand annealing in Saccharomyces cerevisiae.

P2888

P304

1111-1113

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.3261

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2013-08-04T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

255177549

http://www.w3.org/2001/XMLSchema#string

P6179

1029698832

http://www.w3.org/2001/XMLSchema#string

P698

23913125

http://www.w3.org/2001/XMLSchema#string

P921

P932

4153471

http://www.w3.org/2001/XMLSchema#string