Single-molecule dynamics of gating in a neurotransmitter transporter homologue
about
Visualizing functional motions of membrane transporters with molecular dynamics simulationsNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesUltra-stable organic fluorophores for single-molecule researchSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA steered molecular dynamics study of binding and translocation processes in the GABA transporterSubstrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling.Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueSubstrate specificity and ion coupling in the Na+/betaine symporter BetPSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologueInsights into transport mechanism from LeuT engineered to transport tryptophanX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextAlternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetPThe bright future of single-molecule fluorescence imagingThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterConformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.Membrane Phase-Dependent Occlusion of Intramolecular GLUT1 Cavities Demonstrated by Simulations.Toward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling EPR spectroscopyMapping membrane protein structure with fluorescence.Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.Fast Step Transition and State Identification (STaSI) for Discrete Single-Molecule Data Analysis.Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin.Conformational dynamics of ligand-dependent alternating access in LeuT.Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporterMolecular modeling and ligand docking for solute carrier (SLC) transportersConformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocationConformational dynamics of dynamin-like MxA revealed by single-molecule FRET.Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.Cytoplasmic permeation pathway of neurotransmitter transporters.Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysisMutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.
P2860
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P2860
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@ast
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@en
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@nl
type
label
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@ast
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@en
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@nl
prefLabel
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@ast
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@en
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@nl
P2860
P50
P356
P1433
P1476
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
@en
P2093
Yongfang Zhao
P2860
P2888
P304
P356
10.1038/NATURE09057
P407
P577
2010-05-01T00:00:00Z
P5875
P6179
1002314291