Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.
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Antibiotics that target protein synthesisInduced Fit Conformational Changes of a “Reversed Amidine” Heterocycle: Optimized Interactions in a DNA Minor Groove ComplexStructure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycinCrystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sitesMolecular dynamics study of the ribosomal A-site.Aminoglycoside activity observed on single pre-translocation ribosome complexes.Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes.Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactionsBinding of aminoglycoside antibiotics to helix 69 of 23S rRNAUnderstanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal A-site.Targeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-β-D-glucoside and daunomycin binding to tRNA(phe)Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitorsBinding-linked protonation of a DNA minor-groove agentComplete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.Electrostatic interactions in aminoglycoside-RNA complexes.RNA as a drug target: the case of aminoglycosides.Evidence That Antibiotics Bind to Human Mitochondrial Ribosomal RNA Has Implications for Aminoglycoside Toxicity.Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directionsUsing pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding.Identification of neomycin B-binding site in T box antiterminator model RNAThermodynamics of nucleic acid "shape readout" by an aminosugarBiochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on ChromatinA simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding.Calorimetric and spectroscopic studies of aminoglycoside binding to AT-rich DNA triple helices.Sensitivities to parameterization in the size-modified Poisson-Boltzmann equation.RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures.Use of 2-aminopurine as a fluorescent tool for characterizing antibiotic recognition of the bacterial rRNA A-site.Probing the shielding properties of aptameric protective groups.A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures.Aminoglycoside binding to Oxytricha nova telomeric DNA.Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA.Inhibition of Escherichia coli RNase P by oligonucleotide directed misfolding of RNADefining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2'-amino functionality.Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion.Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.Probing the binding of two sugar bearing anticancer agents aristololactam-β-(D)-glucoside and daunomycin to double stranded RNA polynucleotides: a combined spectroscopic and calorimetric study.Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand.
P2860
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P2860
Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@ast
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@en
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@nl
type
label
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@ast
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@en
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@nl
prefLabel
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@ast
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@en
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@nl
P356
P1433
P1476
Thermodynamics of aminoglycosi ...... des to the A site of 16S rRNA.
@en
P2093
Daniel S Pilch
Malvika Kaul
P304
P356
10.1021/BI020130F
P407
P577
2002-06-01T00:00:00Z