Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation - Wikidata - awgldk - TriplyDB

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

http://www.wikidata.org/entity/Q34133622

about

Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response Histone methyltransferases: novel targets for tumor and developmental defects EZH2 in normal hematopoiesis and hematological malignancies Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and Women The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma Product binding enforces the genomic specificity of a yeast polycomb repressive complex.Polycomb genes, miRNA, and their deregulation in B-cell malignancies The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5' End of SS-Overhang Cleavage.Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.Targeting EZH2 and PRC2 dependence as novel anticancer therapy.Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.MTDH is an oncogene in multiple myeloma, which is suppressed by Bortezomib treatment.Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.Epigenetics of hematopoiesis and hematological malignancies.Zebrafish Discoveries in Cancer Epigenetics.EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions.An epigenetic view of B-cell disorders.The NSD family of protein methyltransferases in human cancer.Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma.A comprehensive comparison of tools for differential ChIP-seq analysis.Nucleotide excision repair is a potential therapeutic target in multiple myeloma.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.Mechanisms of Nucleosome Dynamics In Vivo.Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation.The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Epigenetic Mistakes in Neurodevelopmental Disorders.Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma.Impact of Genes Highly Correlated with MMSET Myeloma on the Survival of Non-MMSET Myeloma Patients.Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control.Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.Characterization of H3.3K36M as a tool to study H3K36 methylation in cancer cells.UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.

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Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

http://www.wikidata.org/entity/Q34133622

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

@ast

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

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Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

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type

label

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

@ast

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

@en

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

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prefLabel

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

@ast

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

@en

Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

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JOURNAL.PGEN.1004566

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Histone methyltransferase MMSE ...... in H3K36 and H3K27 methylation

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Christine M Will

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Eliza C Small

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Eugenia G Giannopoulou

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Eva Martinez-Garcia

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Ji-Ping Wang

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Jonathan D Licht

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Marinka Bulic

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Mrinal Y Shah

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Neil L Kelleher

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Qingyang Zhang

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P2860

Model-based analysis of ChIP-Seq (MACS)

An integrated encyclopedia of DNA elements in the human genome

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

The Polycomb group protein EZH2 directly controls DNA methylation

CpG islands recruit a histone H3 lysine 36 demethylase

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

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e1004566

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10.1371/JOURNAL.PGEN.1004566

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9

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10

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Olivier Elemento

Raffaele A. Calogero

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2014-09-04T00:00:00Z

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265343711

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25188243

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4154646

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