Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.
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Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cellsHER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancerProteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast cancer cellsProtein networks as logic functions in development and cancer.HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.Upregulation of heat shock factor 1 transcription activity is associated with hepatocellular carcinoma progression.The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.Biomolecular events in cancer revealed by attractor metagenes.Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPKFBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.Mutant p53 - Heat Shock Response Oncogenic Cooperation: A New Mechanism of Cancer Cell Survival.NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.DAMPs, ageing, and cancer: The 'DAMP Hypothesis'.The crossroads between cancer stem cells and aging.Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapyHeat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuRPolymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypesConserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activationProteotoxic stress of cancer: implication of the heat-shock response in oncogenesis.Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesisHigher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patientsHeat shock factor Hsf1 cooperates with ErbB2 (Her2/Neu) protein to promote mammary tumorigenesis and metastasis.HSF1: Guardian of Proteostasis in CancerHeat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7)Implication of heat shock factors in tumorigenesis: therapeutical potential.Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer.ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis.HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.Heat shock protein as molecular targets for breast cancer therapeutics.Oncogene and non-oncogene addiction in inflammation-associated cancers.Heat shock proteins in multiple myelomaFever, immunity, and molecular adaptations.A Deep Proteome Analysis Identifies the Complete Secretome as the Functional Unit of Human Cardiac Progenitor Cells.Inhibition of the heat shock response by PI103 enhances the cytotoxicity of arsenic trioxide.
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P2860
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@ast
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@en
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@nl
type
label
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@ast
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@en
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@nl
prefLabel
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@ast
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@en
Heat-shock transcription facto ...... nsformation and tumorigenesis.
@nl
P2093
P2860
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Heat-shock transcription facto ...... nsformation and tumorigenesis.
@en
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P2860
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P304
P356
10.1038/ONC.2010.277
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P577
2010-07-12T00:00:00Z
P5875
P6179
1036735919