Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
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Computational methods in drug discoverySubstituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.Allosteric transition: a comparison of two modelsIdentification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypesInvestigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.In silico studies in drug research against neurodegenerative diseases.Have artificial neural networks met expectations in drug discovery as implemented in QSAR framework?N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice.Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyDiscovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs.Computational Methodologies in the Exploration of Marine Natural Product Leads
P2860
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P2860
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@ast
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@en
type
label
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@ast
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@en
prefLabel
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@ast
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@en
P2093
P2860
P50
P356
P1433
P1476
Discovery of 2-(2-benzoxazoyl ...... n to an in vivo tool compound.
@en
P2093
Alexander S Kane
Alice L Rodriguez
Andrew S Felts
Brian A Chauder
Brittney S Bates
Carrie K Jones
Christopher M Olsen
Danny G Winder
Eric S Dawson
Jeffrey P Lamb
P2860
P304
P356
10.1002/CMDC.201100510
P577
2012-01-20T00:00:00Z