Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative
about
Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
P2860
Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Biophysical optimization of a ...... of an iodo-insulin derivative
@ast
Biophysical optimization of a ...... of an iodo-insulin derivative
@en
Biophysical optimization of a ...... of an iodo-insulin derivative
@nl
type
label
Biophysical optimization of a ...... of an iodo-insulin derivative
@ast
Biophysical optimization of a ...... of an iodo-insulin derivative
@en
Biophysical optimization of a ...... of an iodo-insulin derivative
@nl
prefLabel
Biophysical optimization of a ...... of an iodo-insulin derivative
@ast
Biophysical optimization of a ...... of an iodo-insulin derivative
@en
Biophysical optimization of a ...... of an iodo-insulin derivative
@nl
P2093
P2860
P356
P1476
Biophysical optimization of a ...... of an iodo-insulin derivative
@en
P2093
Faramarz Ismail-Beigi
Gabriela P Cox
Jonathan Whittaker
Michael A Weiss
Nelson B Phillips
Vijay Pandyarajan
Yanwu Yang
P2860
P304
23367-23381
P356
10.1074/JBC.M114.588277
P407
P577
2014-07-03T00:00:00Z