Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.
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targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisMycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistanceHigh-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activityHeterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZIdentification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeastThe essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiaeFunctional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiaepara-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosisEvaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Antimicrobial dihydrofolate reductase inhibitors--achievements and future options: review.Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR InhibitorsA Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis.The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.Rational drug design, synthesis and biological evaluation of dihydrofolate reductase inhibitors as antituberculosis agents.Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery.Triclosan inhibition of mycobacterial InhA in Saccharomyces cerevisiae: yeast mitochondria as a novel platform for in vivo antimycolate assays.Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases.
P2860
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P2860
Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.
description
2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@ast
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@en
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@nl
type
label
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@ast
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@en
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@nl
prefLabel
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@ast
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@en
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@nl
P2093
P2860
P1476
Novel Saccharomyces cerevisiae ...... losis dihydrofolate reductase.
@en
P2093
A'Lissa B Gerum
Carol Hopkins Sibley
David P Jacobus
David R Sherman
Jonathan E Ulmer
Norman P Jensen
P2860
P304
P356
10.1128/AAC.46.11.3362-3369.2002
P407
P577
2002-11-01T00:00:00Z