The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.
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Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell ActivationISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes.PIP5K1α inhibition as a therapeutic strategy for prostate cancerTargeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells.The multifaceted role of PIP2 in leukocyte biology.IQGAP1 is a phosphoinositide effector and kinase scaffoldAgonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing.Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.Phosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α.Chiral Brønsted Acid-Catalyzed Enantioselective α-Amidoalkylation Reactions: A Joint Experimental and Predictive Study.Inhibition of PC3 human prostate cancer cell proliferation, invasion and migration by eicosapentaenoic acid and docosahexaenoic acid.Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.Inhibition of Phosphatidylinositol 3-kinease suppresses formation and progression of experimental abdominal aortic aneurysms.Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.Cancer: Lipid kinase PIP5K1α as a new target in prostate cancer.NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase α and its implication in breast cancer cell proliferation.The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer.Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
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P2860
The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@ast
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@en
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@nl
type
label
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@ast
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@en
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@nl
prefLabel
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@ast
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@en
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@nl
P2093
P2860
P50
P356
P1476
The role of PI3K/AKT-related P ...... t of advanced prostate cancer.
@en
P2093
Andreas Hedblom
Julius Semenas
Liliya Shcherbina
Martin E Johansson
Olov Sterner
Pirkko Härkönen
Rikard Larsson
P2860
P304
P356
10.1073/PNAS.1405801111
P407
P577
2014-07-28T00:00:00Z