The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.
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Oxidative stress, mitochondrial dysfunction, and agingMitophagy plays a central role in mitochondrial ageingHigh-throughput sequencing in mitochondrial DNA researchMitochondrial DNA heteroplasmy in the emerging field of massively parallel sequencingHeterogeneous tissue distribution of a mitochondrial DNA polymorphism in heteroplasmic subjects without mitochondrial disordersDugesia sicula (Platyhelminthes, Tricladida): the colonizing success of an asexual PlanarianPlatelet recovery and survival measured in patients by quantitative polymerase chain reaction of mitochondrial DNA.Mitochondrial DNA variants in obesityThe age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method.Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals.A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity.Heteroplasmy of the human mtDNA control region remains constant during life.Mitochondrial DNA alterations and reduced mitochondrial function in agingA sensitive denaturing gradient-Gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region 1 of the human mtDNA control region.Neutral mitochondrial heteroplasmy and the influence of aging.Mitochondrial longevity pathwaysFrequency and pattern of heteroplasmy in the complete human mitochondrial genome.Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.mtDNA Mutations and Their Role in Aging, Diseases and Forensic SciencesAge-Related and Heteroplasmy-Related Variation in Human mtDNA Copy NumberMitochondrial Heteroplasmy.Mitochondrial DNA heteroplasmy in human health and disease.Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes.Mitochondrial DNA analysis of Swedish population samples.No relationship found between point heteroplasmy in mitochondrial DNA control region and age range, sex and haplogroup in human hairs.Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.Sensitive detection of mitochondrial DNA variants for analysis of mitochondrial DNA-enriched extracts from frozen tumor tissue.Applications of Probe Capture Enrichment Next Generation Sequencing for Whole Mitochondrial Genome and 426 Nuclear SNPs for Forensically Challenging Samples.Differential distribution of human mitochondrial DNA in somatic tissues and hairs.Defeating numts: semi-pure mitochondrial DNA from eggs and simple purification methods for field-collected wildlife tissues.Primer effect in the detection of mitochondrial DNA point heteroplasmy by automated sequencing.Optimization of human mtDNA control region sequencing for forensic applications.Factors affecting the detection and quantification of mitochondrial point heteroplasmy using Sanger sequencing and SNaPshot minisequencing.Mitochondrial DNA heteroplasmy or artefacts--a matter of the amplification strategy?Tumor-Specific Mitochondrial DNA Variants Are Rarely Detected in Cell-Free DNA.
P2860
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P2860
The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.
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The frequency of heteroplasmy ...... types and increases with age.
@ast
The frequency of heteroplasmy ...... types and increases with age.
@en
The frequency of heteroplasmy ...... types and increases with age.
@nl
type
label
The frequency of heteroplasmy ...... types and increases with age.
@ast
The frequency of heteroplasmy ...... types and increases with age.
@en
The frequency of heteroplasmy ...... types and increases with age.
@nl
prefLabel
The frequency of heteroplasmy ...... types and increases with age.
@ast
The frequency of heteroplasmy ...... types and increases with age.
@en
The frequency of heteroplasmy ...... types and increases with age.
@nl
P2093
P2860
P356
P1476
The frequency of heteroplasmy ...... types and increases with age.
@en
P2093
Anderson WW
Calloway CD
Herrin GL Jr
Reynolds RL
P2860
P304
P356
10.1086/302844
P407
P577
2000-03-17T00:00:00Z