Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.
about
Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease.Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviorsA polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorderInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATA competitive inhibitor traps LeuT in an open-to-out conformation.Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformationSubstrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologueX-ray structures of LeuT in substrate-free outward-open and apo inward-open statesStructures of LeuT in bicelles define conformation and substrate binding in a membrane-like contextMonoamine TransportDevelopmental effects of SSRIs: lessons learned from animal studies.Substrate binding and formation of an occluded state in the leucine transporter.How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male miceReserpine-induced reduction in norepinephrine transporter function requires catecholamine storage vesicles.Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.Discovery of novel selective serotonin reuptake inhibitors through development of a protein-based pharmacophore.Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporterMicroseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuTEthiopathogenesis of depressive disordersPharmacogenomics in the treatment of narcolepsy.Pharmacogenetics of monoamine transporters.Identification of a novel selective serotonin reuptake inhibitor by coupling monoamine transporter-based virtual screening and rational molecular hybridizationAnalysis of Association between Norepinephrine Transporter Gene Polymorphisms and Personality Traits of NEO-FFI in a Japanese PopulationEnergy landscape of LeuT from molecular simulationsMonoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants.Pharmacogenomics and antidepressant drugs.Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in DrosophilaIn vivo monitoring of serotonin in the striatum of freely moving rats with one minute temporal resolution by online microdialysis-capillary high-performance liquid chromatography at elevated temperature and pressure.Common genetic risk factors for psychiatric and simatic disorders.-141C insertion/deletion polymorphism of the dopamine D2 receptor gene is associated with schizophrenia in Chinese Han population: Evidence from an ethnic group-specific meta-analysis.Comparative modeling of the human monoamine transporters: similarities in substrate binding.NGS for Sequence Variants.Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.Homeostatic mechanisms in dopamine synthesis and release: a mathematical model.Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR.
P2860
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P2860
Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Monoamine transporter gene str ...... c and other complex disorders.
@ast
Monoamine transporter gene str ...... c and other complex disorders.
@en
Monoamine transporter gene str ...... c and other complex disorders.
@nl
type
label
Monoamine transporter gene str ...... c and other complex disorders.
@ast
Monoamine transporter gene str ...... c and other complex disorders.
@en
Monoamine transporter gene str ...... c and other complex disorders.
@nl
prefLabel
Monoamine transporter gene str ...... c and other complex disorders.
@ast
Monoamine transporter gene str ...... c and other complex disorders.
@en
Monoamine transporter gene str ...... c and other complex disorders.
@nl
P2860
P356
P1476
Monoamine transporter gene str ...... c and other complex disorders.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.TPJ.6500106
P577
2002-01-01T00:00:00Z
P5875
P6179
1022120284