Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. - Wikidata - awgldk - TriplyDB

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

http://www.wikidata.org/entity/Q34157359

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes Recent advances in malaria drug discovery Diversity-oriented synthesis yields novel multistage antimalarial inhibitors New developments in anti-malarial target candidate and product profiles Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase Diversity oriented synthesis for novel anti-malarials.Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents Translational synthetic chemistry.Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.Rapid, scalable assembly of stereochemically rich, mono- and bicyclic acyl sultams Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum Utilizing diversity-oriented synthesis in antimicrobial drug discovery.Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Hits, leads and drugs against malaria through diversity-oriented synthesis.New insight-guided approaches to detect, cure, prevent and eliminate malaria.Photoassisted diversity-oriented synthesis: accessing 2,6-epoxyazocane (oxamorphan) cores.Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.

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P2860

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

http://www.wikidata.org/entity/Q34157359

description

2011 nî lūn-bûn

@nan

2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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type

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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ACS Medicinal Chemistry Letters

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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

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P2093

Benito Munoz

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Carol Mulrooney

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Christopher P Austin

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Craig J Thomas

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Daniela Masi

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Eamon Comer

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Eric H Ekland

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Jennifer A Beaudoin

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Jeremy R Duvall

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Jing Yuan

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P2860

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors

Malaria: progress, perils, and prospects for eradication

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Target-oriented and diversity-oriented organic synthesis in drug discovery

A planning strategy for diversity-oriented synthesis

Towards the optimal screening collection: a synthesis strategy

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

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10.1021/ML200244K

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2

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David A. Fidock

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2011-12-22T00:00:00Z

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