Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognitionQ&A;: Evolutionary capacitanceContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisMolecular mechanisms of robustness in plantsExpanding proteostasis by membrane trafficking networksQuality control and fate determination of Hsp90 client proteinsChaperone machines for protein folding, unfolding and disaggregationRole of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegansRebels with a cause: molecular features and physiological consequences of yeast prionsMapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitryGenetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphismsFitness trade-offs restrict the evolution of resistance to amphotericin BC-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesisBio-ethanol production by a novel autochthonous thermo-tolerant yeast isolated from wastewaterLooking for adaptive footprints in the HSP90AA1 ovine geneExplaining bathymetric diversity patterns in marine benthic invertebrates and demersal fishes: physiological contributions to adaptation of life at depthCryptic genetic variation can make “irreducible complexity” a common mode of adaptation in sexual populationsDifferential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Genetic assimilation: a review of its potential proximate causes and evolutionary consequences.Histone variant HTZ1 shows extensive epistasis with, but does not increase robustness to, new mutations.Rapid evolution of phenotypic plasticity and shifting thresholds of genetic assimilation in the nematode Caenorhabditis remaneiInterplay between chaperones and protein disorder promotes the evolution of protein networks.Negative feedback in genetic circuits confers evolutionary resilience and capacitance.MicroRNAs and their roles in developmental canalization.Genomic analysis of QTLs and genes altering natural variation in stochastic noise.Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations.Hsp90 depletion goes wildPrions are a common mechanism for phenotypic inheritance in wild yeasts.Does the central dogma still stand?Advances in quantitative trait analysis in yeast.Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.Mitochondrial-nuclear epistasis contributes to phenotypic variation and coadaptation in natural isolates of Saccharomyces cerevisiaeThe Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.Lessons from model organisms: phenotypic robustness and missing heritability in complex disease.Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.Generators of phenotypic diversity in the evolution of pathogenic microorganisms.Hsp90 promotes kinase evolutionSingle-cell phenomics reveals intra-species variation of phenotypic noise in yeast.HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease.
P2860
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P2860
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@ast
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@en
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@nl
type
label
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@ast
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@en
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@nl
prefLabel
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@ast
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@en
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@nl
P2860
P356
P1433
P1476
Hsp90 and environmental stress transform the adaptive value of natural genetic variation.
@en
P2860
P304
P356
10.1126/SCIENCE.1195487
P407
P577
2010-12-01T00:00:00Z