Yeast Sen1 helicase protects the genome from transcription-associated instability.
about
Out of balance: R-loops in human diseaseHuman senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationProtein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptideA SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damageTranscription dynamics in plant immunityDisengaging polymerase: terminating RNA polymerase II transcription in budding yeastBreaking bad: R-loops and genome integrityReplication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stabilityR-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasThe THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningA bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast.Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repairSen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.Yeast transcription termination factor Rtt103 functions in DNA damage responseSenataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiaeThe PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p.Interactions of Sen1, Nrd1, and Nab3 with multiple phosphorylated forms of the Rpb1 C-terminal domain in Saccharomyces cerevisiae.Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1.Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5'- to 3'-Helicase Activity with a Preference for Translocation on DNA Rather than RNAThe DEAD-box RNA helicase Dbp2 connects RNA quality control with repression of aberrant transcription.The Causes and Consequences of Topological Stress during DNA ReplicationTranscriptional termination in mammals: Stopping the RNA polymerase II juggernautRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeSen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiaeTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionRNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplateS1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination.Mechanisms of genome instability induced by RNA-processing defects.Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase familyA double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionPathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeDNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation.Ending the message: poly(A) signals then and nowRNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instabilitySaccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage
P2860
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P2860
Yeast Sen1 helicase protects the genome from transcription-associated instability.
description
2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@ast
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@en
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@nl
type
label
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@ast
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@en
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@nl
prefLabel
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@ast
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@en
Yeast Sen1 helicase protects the genome from transcription-associated instability.
@nl
P2093
P2860
P50
P1433
P1476
Yeast Sen1 helicase protects the genome from transcription-associated instability
@en
P2093
Ana G Rondón
Hannah E Mischo
P2860
P356
10.1016/J.MOLCEL.2010.12.007
P577
2011-01-01T00:00:00Z