Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. - Wikidata - awgldk - TriplyDB

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34157974

about

Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate Prognostification of ALL by Cytogenetics In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells Germline genomic variants associated with childhood acute lymphoblastic leukemia Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia.Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia.The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number Optimizing antimetabolite-based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia.Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.The emergence of resistance to targeted cancer therapeutics.Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial.Resistance to antifolates.Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404).Contribution of tumoral and host solute carriers to clinical drug response.Outcomes after induction failure in childhood acute lymphoblastic leukemia.Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy.Pharmacogenomics in pediatric leukemia.Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.Risk factors for relapse in childhood acute lymphoblastic leukemia: prediction and prevention.Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.Treatment of Childhood T-Cell Lymphoblastic Lymphoma-Long-Term Results of the SFOP LMT96 Trial.Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species.Dose reduction of coadministered 6-mercaptopurine decreases myelotoxicity following high-dose methotrexate in childhood leukemia.Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia.Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.

P2860

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P2860

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34157974

description

1994 nî lūn-bûn

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1994 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1994年の論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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1994年論文

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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Journal of Clinical Investigation

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Blast cell methotrexate-polygl ...... acute lymphoblastic leukemia.

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C H Pui

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G K Rivera

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P2860

Receptor-mediated folate accumulation is regulated by the cellular folate content

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase.

Potocytosis: sequestration and transport of small molecules by caveolae.

Polyglutamation of methotrexate. Is methotrexate a prodrug?

Competitive protein binding assay for methotrexate.

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia.

Folate-dependent enzymes in cultured Chinese hamster cells: folypolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine.

Biology and treatment of acute lymphoblastic leukemia.

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1996-2001

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scholarly article

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10.1172/JCI117552

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5

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