Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.
about
High-level pacidamycin resistance in Pseudomonas aeruginosa is mediated by an opp oligopeptide permease encoded by the opp-fabI operontRNAs as regulators of biological processesRevealing the first uridyl peptide antibiotic biosynthetic gene cluster and probing pacidamycin biosynthesisActivation of the pacidamycin PacL adenylation domain by MbtH-like proteins.Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation.Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888.Identification of Mur34 as the novel negative regulator responsible for the biosynthesis of muraymycin in Streptomyces sp. NRRL30471Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly linestRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics.Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics.Identification of novel mureidomycin analogues via rational activation of a cryptic gene cluster in Streptomyces roseosporus NRRL 15998.Biosynthesis of albomycin δ(2) provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates.Nonribosomal Peptide Synthesis-Principles and Prospects.Draft genome sequence of Streptomyces sp. strain SS, which produces a series of uridyl peptide antibiotic sansanmycins.SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in Streptomyces sp. strain SS through a feedback mechanism.Improving the N-terminal diversity of sansanmycin through mutasynthesis.Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistancePleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.Antibiotics as signal molecules.Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery.Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery.Biosynthesis of natural products containing β-amino acids.Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.Nature's combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces.Chemical logic and enzymatic machinery for biological assembly of peptidyl nucleoside antibioticsTargeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins.Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.Synthesis and structure confirmation of fuscachelins A and B, structurally unique natural product siderophores from Thermobifida fusca.Crystallization and preliminary X-ray analysis of Pac17 from the pacidamycin-biosynthetic cluster of Streptomyces coeruleorubidus.Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY.Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibioticsIdentification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis.Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria.Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471.Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.
P2860
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P2860
Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@ast
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@en
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@nl
type
label
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@ast
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@en
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@nl
prefLabel
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@ast
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@en
Identification of the biosynth ...... ptidyl nucleoside antibiotics.
@nl
P2860
P356
P1476
Identification of the biosynth ...... eptidyl nucleoside antibiotics
@en
P2093
Christopher T Walsh
Wenjun Zhang
P2860
P304
16828-16833
P356
10.1073/PNAS.1011557107
P407
P577
2010-09-08T00:00:00Z