The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.
about
TRPV1: on the road to pain reliefPhysiology and pharmacology of the vanilloid receptorActivation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and functionThe cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurinHarnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other DiseasesThe mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependenceTRPV1 and SP: key elements for sepsis outcome?Differential Activation of TRP Channels in the Adult Rat Spinal Substantia Gelatinosa by Stereoisomers of Plant-Derived ChemicalsTRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the ratLASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic painTRPV1: A Potential Drug Target for Treating Various Diseases.Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies.Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain.Characterization of in vitro metabolism of capsazepine, a vanilloid transient receptor potential channel antagonist, by liquid chromatography quadrupole ion trap mass spectrometry.Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermiaTransient Receptor Potential Vanilloid 1 is essential for cisplatin-induced heat hyperalgesia in miceCharacterization of [6]-gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry.Pharmacokinetics of the TRPV1 antagonist ABT-102 in healthy human volunteers: population analysis of data from 3 phase 1 trials.LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligationMapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritisThe endocannabinoid system and painAntinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.Spatio-temporal expression and functional involvement of transient receptor potential vanilloid 1 in diabetic mechanical allodynia in rats.Wu-tou decoction inhibits chronic inflammatory pain in mice: participation of TRPV1 and TRPA1 ion channels.Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.Expression and Regulation of Cav3.2 T-Type Calcium Channels during Inflammatory Hyperalgesia in Mouse Dorsal Root Ganglion Neurons.Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential.Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC.Cell signaling and the genesis of neuropathic pain.TRPV1 receptor in expression of opioid-induced hyperalgesiaNew targets for neuropathic pain therapeutics.Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic ContentTRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammationSimvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis.TRPpathies.P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons.Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.
P2860
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P2860
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@ast
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@en
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@nl
type
label
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@ast
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@en
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@nl
prefLabel
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@ast
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@en
The VR1 antagonist capsazepine ...... ammatory and neuropathic pain.
@nl
P2093
P356
P1476
The VR1 antagonist capsazepine ...... lammatory and neuropathic pain
@en
P2093
Alyson J Fox
Katharine M Walker
Laszlo Urban
Mohanjit Panesar
Sadhana Patel
Stephen J Medhurst
P356
10.1124/JPET.102.042010
P407
P577
2003-01-01T00:00:00Z