FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
about
Analysing the visible conformational substates of the FK506-binding protein FKBP12Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.Intracellular Zinc Modulates Cardiac Ryanodine Receptor-mediated Calcium Release.Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep.Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.The sarcoplasmic reticulum and the evolution of the vertebrate heart.Conformational Dynamics in FKBP Domains: Relevance to Molecular Signaling and Drug DesignExamining a new role for zinc in regulating calcium release in cardiac muscle.Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation.The ryanodine receptor provides high throughput Ca2+-release but is precisely regulated by networks of associated proteins: a focus on proteins relevant to phosphorylation.Is there something fishy about the regulation of the ryanodine receptor in the fish heart?Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation.Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison.Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding.Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes.Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour
P2860
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P2860
FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.
description
2012 nî lūn-bûn
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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2012 թվականի փետրվարին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@ast
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@en
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@nl
type
label
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@ast
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@en
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@nl
prefLabel
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@ast
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@en
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@nl
P2093
P2860
P50
P1433
P1476
FKBP12 activates the cardiac r ...... nd is antagonised by FKBP12.6.
@en
P2093
Elena Galfré
Mano Sitsapesan
Nathan R Zaccai
Rebecca Sitsapesan
Stephen O'Neill
P2860
P304
P356
10.1371/JOURNAL.PONE.0031956
P407
P577
2012-02-21T00:00:00Z