Structure and hydration of the DNA-human topoisomerase I covalent complex.

Structure and hydration of the DNA-human topoisomerase I covalent complex.

Item
http://www.wikidata.org/entity/Q34175951
Rotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxationReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantThe open state of human topoisomerase I as probed by molecular dynamics simulationRecovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.Molecular dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration.The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.Human topoisomerase I C-terminal domain fragment containing the active site tyrosine is a molten globule: implication for the formation of competent productive complex.Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.Protein concerted motions in the DNA-human topoisomerase I complex.Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics.Molecular dynamics studies on free and bound targets of the bovine papillomavirus type I e2 protein: the protein binding effect on DNA and the recognition mechanism
P2860

Structure and hydration of the DNA-human topoisomerase I covalent complex.

Item
http://www.wikidata.org/entity/Q34175951
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@ast
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@en
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@nl
type
label
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@ast
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@en
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@nl
prefLabel
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@ast
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@en
Structure and hydration of the DNA-human topoisomerase I covalent complex.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Structure and hydration of the DNA-human topoisomerase I covalent complex
@en
P2093
P2860
P304
P31
P356
10.1016/S0006-3495(01)75716-5
P407
P433
P478
P50
P577
P698
P932