Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
about
Protein kinases and phosphatases in the control of cell fateDinosaurs and ancient civilizations: reflections on the treatment of cancerMnk kinase pathway: Cellular functions and biological outcomesThe combination of RAD001 and NVP-BEZ235 exerts synergistic anticancer activity against non-small cell lung cancer in vitro and in vivoTargeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancerIdentification of a gene expression driven progression pathway in myxoid liposarcoma.MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome.The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.The interconnectedness of cancer cell signaling.MicroRNAs and ovarian functionUp-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma CellsCGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.Targeting Mnks for cancer therapy.Protein phosphatase 2A: a target for anticancer therapy.Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and protein phosphatase 2A (PP2A) on extracellular matrixTargeting translation: eIF4E as an emerging anticancer drug target.Translational control of the fibroblast-extracellular matrix association: An application to pulmonary fibrosis.Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells.Targeting of protein translation as a new treatment paradigm for prostate cancer.Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integrationRegulation of protein translation initiation in response to ionizing radiation.AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines.Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression.Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis.The impact of phosphatases on proliferative and survival signaling in cancer.Signaling pathways involved in the regulation of mRNA translation.Proteasome inhibition leads to dephosphorylation and downregulation of protein expression of members of the Akt/mTOR pathway in MCL.Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer.Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines.
P2860
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P2860
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@ast
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@en
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@nl
type
label
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@ast
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@en
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@nl
prefLabel
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@ast
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@en
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@nl
P2093
P2860
P356
P1433
P1476
Protein phosphatase 2A negativ ...... sphorylation of Mnk and eIF4E.
@en
P2093
Fadlo R Khuri
Rikiro Fukunaga
Shi-Yong Sun
Takeshi Ueda
Xingming Deng
P2860
P304
P356
10.1593/NEO.10704
P577
2010-10-01T00:00:00Z