Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. - Wikidata - awgldk - TriplyDB

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

http://www.wikidata.org/entity/Q34177503

about

Deregulation of RGS2 in cardiovascular diseases The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function Cholinergic activity as a new target in diseases of the heart Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits Structural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex Regulators of G-protein signaling in the heart and their potential as therapeutic targets.Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin II in cultured vascular smooth muscles RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality.AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets.Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.Upregulation of regulator of G-protein signaling 2 in the sclera of a form deprivation myopic animal model Non-dipping and arterial hypertension depend on clinical factors rather than on genetic variability of ACE and RGS2 genes in patients with type 1 diabetes.Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.Regulation of Gβγi-dependent PLC-β3 activity in smooth muscle: inhibitory phosphorylation of PLC-β3 by PKA and PKG and stimulatory phosphorylation of Gαi-GTPase-activating protein RGS2 by PKG.Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.Renal actions of RGS2 control blood pressure.Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway.Does airway smooth muscle express an inflammatory phenotype in asthma?Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer's disease.RGS2: a "turn-off" in hypertension Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses.Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma.Anthrax lethal toxin-induced gene expression changes in mouse lung.Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids Regulation of Renal Hemodynamics and Function by RGS2.

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P2860

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

http://www.wikidata.org/entity/Q34177503

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@ast

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@en

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@nl

type

label

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@ast

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@en

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@nl

prefLabel

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@ast

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@en

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@nl

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Journal of Clinical Investigation

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Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

@en

P2093

Anthony J Muslin

http://www.w3.org/2001/XMLSchema#string

Antonio Oliveira-dos-Santos

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J Michael Wyss

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Josef M Penninger

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Kendall J Blumer

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Kevin M Kaltenbronn

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Man-Hee Rhee

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Ning Peng

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Robert P Mecham

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Russell H Knutsen

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P2860

RGS2/G0S8 is a selective inhibitor of Gqalpha function

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast

Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension

G protein selectivity is a determinant of RGS2 function.

RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.

Molecular mechanisms of human hypertension.

Gene targeting approaches to analyzing hypertension.

RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.

Regulation of T cell activation, anxiety, and male aggression by RGS2.

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10.1172/JCI15598

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4

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111

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12588882

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151918

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