Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications.
about
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stressSIRT1 regulates endothelial Notch signaling in lung cancer.A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studiesMechanisms of dysfunction in senescent pulmonary endothelium.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Time to Decide? Dynamical Analysis Predicts Partial Tip/Stalk Patterning States Arise during Angiogenesis.Are sirtuins viable targets for improving healthspan and lifespan?Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cellsCircadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1.Sirtuin 1 (SIRT1): the misunderstood HDAC.A patent review of sirtuin activators: an update.Diversification of NAD biological role: the importance of location.New assays and approaches for discovery and design of Sirtuin modulators.Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy.Sirtuins Expression and Their Role in Retinal Diseases.Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop.Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.Mocetinostat combined with gemcitabine for the treatment of leiomyosarcoma: Preclinical correlates.The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis.Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan.
P2860
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P2860
Advances in characterization of human sirtuin isoforms: chemistries, targets and therapeutic applications.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Advances in characterization o ...... and therapeutic applications.
@ast
Advances in characterization o ...... and therapeutic applications.
@en
Advances in characterization o ...... and therapeutic applications.
@nl
type
label
Advances in characterization o ...... and therapeutic applications.
@ast
Advances in characterization o ...... and therapeutic applications.
@en
Advances in characterization o ...... and therapeutic applications.
@nl
prefLabel
Advances in characterization o ...... and therapeutic applications.
@ast
Advances in characterization o ...... and therapeutic applications.
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Advances in characterization o ...... and therapeutic applications.
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P1476
Advances in characterization o ...... s and therapeutic applications
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P2093
P304
P356
10.2174/092986711795590084
P50
P577
2011-01-01T00:00:00Z