Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells.
about
The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic coreA Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeastGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseAssociation of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapyIdentification of ITPA on chromosome 20 as a susceptibility gene for young-onset tuberculosis.Inosine triphosphate pyrophosphohydrolase (ITPA) polymorphic sequence variants in adult hematological malignancy patients and possible association with mitochondrial DNA defectsITPA (inosine triphosphate pyrophosphatase): from surveillance of nucleotide pools to human disease and pharmacogeneticsModulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.A four-gene signature predicts survival in clear-cell renal-cell carcinomaDCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia.RNAi mediated gene silencing of ITPA using a targeted nanocarrier: Apoptosis induction in SKBR3 cancer cells.The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine.Variant Inosine Triphosphatase Phenotypes Are Associated With Increased Ribavirin Triphosphate Levels.Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera.A commensal strain of Staphylococcus epidermidis protects against skin neoplasia.Gene dosage effects in yeast support broader roles for the LOG1, HAM1 and DUT1 genes in detoxification of nucleotide analogues.Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
P2860
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P2860
Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells.
description
2012 nî lūn-bûn
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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2012 թվականի փետրվարին հրատարակված գիտական հոդված
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@ast
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@en
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@nl
type
label
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@ast
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@en
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@nl
prefLabel
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@ast
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@en
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@nl
P2093
P2860
P1433
P1476
Pivotal role of inosine tripho ...... n of apoptosis in human cells.
@en
P2093
Hernando Lopez-Bertoni
Irina S-R Waisertreiger
Miriam Rose Menezes
Youri I Pavlov
P2860
P304
P356
10.1371/JOURNAL.PONE.0032313
P407
P577
2012-02-27T00:00:00Z