A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. - Wikidata - awgldk - TriplyDB

A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division.

A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division.

http://www.wikidata.org/entity/Q34186619

about

MiD49 and MiD51, new components of the mitochondrial fission machinery.Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission Crystal structure of nucleotide-free dynamin Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission Mitochondrial morphology in metabolic diseases Mitochondrial dynamics in diabetic cardiomyopathy Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules.Dynamin-related protein 1 (Drp1) promotes structural intermediates of membrane division In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission.Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia.In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells Autophagy-mediated turnover of dynamin-related protein 1.Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction.Dynamin-related protein 1 as a therapeutic target in cardiac arrest A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction.How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane.Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation Allosteric modulation of Drp1 mechanoenzyme assembly and mitochondrial fission by the variable domain.Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes.The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria Characterization of two novel intronic OPA1 mutations resulting in aberrant pre-mRNA splicing Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.Molecular mechanism of DRP1 assembly studied in vitro by cryo-electron microscopy.Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.Mitochondrial fission/fusion and cardiomyopathy.DNM1L-related mitochondrial fission defect presenting as refractory epilepsy.The power of yeast to model diseases of the powerhouse of the cell.Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals.Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!Mitochondrial division: molecular machinery and physiological functions.

P2860

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P2860

A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division.

http://www.wikidata.org/entity/Q34186619

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

A lethal de novo mutation in t ...... ly and mitochondrial division.

@ast

A lethal de novo mutation in t ...... ly and mitochondrial division.

@en

A lethal de novo mutation in t ...... ly and mitochondrial division.

@nl

type

label

A lethal de novo mutation in t ...... ly and mitochondrial division.

@ast

A lethal de novo mutation in t ...... ly and mitochondrial division.

@en

A lethal de novo mutation in t ...... ly and mitochondrial division.

@nl

prefLabel

A lethal de novo mutation in t ...... ly and mitochondrial division.

@ast

A lethal de novo mutation in t ...... ly and mitochondrial division.

@en

A lethal de novo mutation in t ...... ly and mitochondrial division.

@nl

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JBC.M110.142430

P1433

Journal of Biological Chemistry

P1476

A lethal de novo mutation in t ...... ly and mitochondrial division.

@en

P2093

Ammon E Posey

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Cara Marie Manlandro

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Chuang-Rung Chang

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Craig Blackstone

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Damien Arnoult

http://www.w3.org/2001/XMLSchema#string

Julia Stadler

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R Blake Hill

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P2860

Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B

Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins

Dnm1 forms spirals that are structurally tailored to fit mitochondria.

Mdv1 interacts with assembled dnm1 to promote mitochondrial division.

Mitochondria: dynamic organelles in disease, aging, and development

Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1

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32494-32503

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42

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285

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20696759

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2952251

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