LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. - Wikidata - awgldk - TriplyDB

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

http://www.wikidata.org/entity/Q34191636

about

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography Cancer-associated fibroblasts in digestive tumors Rho GTPases in collective cell migration Cells activated for wound repair have the potential to direct collective invasion of an epithelium.Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability A computer-assisted 3D model for analyzing the aggregation of tumorigenic cells reveals specialized behaviors and unique cell types that facilitate aggregate coalescence Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs Keratinocyte migration in the developing eyelid requires LIMK2 Myxoma virus oncolytic efficiency can be enhanced through chemical or genetic disruption of the actin cytoskeleton Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.A novel Rho-dependent pathway that drives interaction of fascin-1 with p-Lin-11/Isl-1/Mec-3 kinase (LIMK) 1/2 to promote fascin-1/actin binding and filopodia stability.Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion.Chemotaxis in cancer An epigenetically distinct breast cancer cell subpopulation promotes collective invasion Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform MiR-20a inhibits cutaneous squamous cell carcinoma metastasis and proliferation by directly targeting LIMK1 LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis.Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption.Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion.Aggregatibacter actinomycetemcomitans leukotoxin (LtxA; Leukothera) induces cofilin dephosphorylation and actin depolymerization during killing of malignant monocytes.ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.Movers and shakers: cell cytoskeleton in cancer metastasis.Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins.Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis.The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis.

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P2860

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells.

http://www.wikidata.org/entity/Q34191636

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

LIM kinases are required for i ...... umor-associated stromal cells.

@ast

LIM kinases are required for i ...... umor-associated stromal cells.

@en

LIM kinases are required for i ...... umor-associated stromal cells.

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type

label

LIM kinases are required for i ...... umor-associated stromal cells.

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LIM kinases are required for i ...... umor-associated stromal cells.

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LIM kinases are required for i ...... umor-associated stromal cells.

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prefLabel

LIM kinases are required for i ...... umor-associated stromal cells.

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LIM kinases are required for i ...... umor-associated stromal cells.

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LIM kinases are required for i ...... umor-associated stromal cells.

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Journal of Cell Biology

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LIM kinases are required for i ...... umor-associated stromal cells.

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Ang Li

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Daniel R Croft

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Diane Crighton

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Elisabeth Trivier

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Grant Wickman

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Ireen König

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John Dawson

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June Munro

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Laura Machesky

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Pierre Morin

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P2860

The Hallmarks of Cancer

The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

Rocks: multifunctional kinases in cell behaviour

Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments

MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

The matrix corroded: podosomes and invadopodia in extracellular matrix degradation

LIM kinases: function, regulation and association with human disease

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

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169-185

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scholarly article

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10.1083/JCB.201002041

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1

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191

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Michael F. Olson

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2010-09-27T00:00:00Z

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46578463

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20876278

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2953444

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