C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?
about
C9orf72's Interaction with Rab GTPases-Modulation of Membrane Traffic and AutophagyG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeEarly microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutationAntisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.Modifiers of solid RNP granules control normal RNP dynamics and mRNA activity in early developmentC9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits.Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathwaysSuppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders.Compromised MAPK signaling in human diseases: an update.Molecular basis of ALS and FTD: implications for translational studies.Genetics of FTLD: overview and what else we can expect from genetic studies.Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies.C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers.Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.C9orf72 is required for proper macrophage and microglial function in mice.Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases.The Genetics of Monogenic Frontotemporal Dementia.G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.Role of Genetics and Epigenetics in the Pathogenesis of Alzheimer's Disease and Frontotemporal Dementia.Familial Amyotrophic Lateral Sclerosis.Antisense oligonucleotides in neurological disorders.Whole blood transcriptome analysis in amyotrophic lateral sclerosis: A biomarker study.From Mouse Models to Human Disease: An Approach for Amyotrophic Lateral Sclerosis
P2860
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P2860
C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@ast
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@en
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@nl
type
label
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@ast
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@en
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@nl
prefLabel
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@ast
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@en
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@nl
P2860
P921
P1476
C9orf72 amyotrophic lateral sc ...... tia: gain or loss of function?
@en
P2093
Adrian M Isaacs
Sarah Mizielinska
P2860
P304
P356
10.1097/WCO.0000000000000130
P5008
P577
2014-10-01T00:00:00Z