Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia--genetic short limbed dwarfism.
about
Genetic architecture of body size in mammalsSixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasiasNF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cellsPP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGFPathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure.A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia.De novo achondroplasia causing four consecutive unsuccessful pregnancies: a case report.Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model.FGFR3 targeting strategies for achondroplasia.Height matters-from monogenic disorders to normal variation.Fibroblast growth factor (FGF) signaling in development and skeletal diseases.Advances in treatment of achondroplasia and osteoarthritis.Sleep disordered breathing in children with achondroplasia.The B55α regulatory subunit of protein phosphatase 2A mediates fibroblast growth factor-induced p107 dephosphorylation and growth arrest in chondrocytes.Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domainChronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice.Production of plasma membrane vesicles with chloride salts and their utility as a cell membrane mimetic for biophysical characterization of membrane protein interactions.Cartilage dysplasia and tissue mineralization in the rat following administration of a FGF receptor tyrosine kinase inhibitor.Review of the recently defined molecular mechanisms underlying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia.Functional characteristics of mesenchymal stem cells derived from the adipose tissue of a patient with achondroplasia.Emerging targeted drug therapies in skeletal dysplasias.
P2860
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P2860
Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia--genetic short limbed dwarfism.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@ast
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@en
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@nl
type
label
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@ast
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@en
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@nl
prefLabel
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@ast
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@en
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@nl
P2093
P356
P1433
P1476
Fibroblast growth factor recep ...... genetic short limbed dwarfism.
@en
P2093
Avner Yayon
David Aviezer
Myriam Golembo
P304
P356
10.2174/1389450033490993
P577
2003-07-01T00:00:00Z