Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk - Wikidata - awgldk - TriplyDB

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

http://www.wikidata.org/entity/Q34213805

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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state of play Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review TM6SF2 E167K Variant, a Novel Genetic Susceptibility Variant, Contributing to Nonalcoholic Fatty Liver Disease Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis Insights into blood lipids from rare variant discovery Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD-A Systematic Review How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Liver enzymes, metabolomics and genome-wide association studies: from systems biology to the personalized medicine Susceptibility of Different Mouse Wild Type Strains to Develop Diet-Induced NAFLD/AFLD-Associated Liver Disease Transmembrane 6 superfamily 1 (Tm6sf1) is a novel lysosomal transmembrane protein Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility Genetic predisposition in nonalcoholic fatty liver disease.Leveraging human genetics to guide drug target discovery.FINEMAP: efficient variable selection using summary data from genome-wide association studies.Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics.No large-effect low-frequency coding variation found for myocardial infarction A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins.TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.Rare variant association studies: considerations, challenges and opportunities.Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.Genome-wide association studies and contribution to cardiovascular physiology A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.Replication analysis of genetic association of the NCAN-CILP2 region with plasma lipid levels and non-alcoholic fatty liver disease in Asian and Pacific ethnic groups The impact of low-frequency and rare variants on lipid levels.Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.Meta-analysis of the influence of TM6SF2 E167K variant on Plasma Concentration of Aminotransferases across different Populations and Diverse Liver Phenotypes.Insights from Genome-Wide Association Analyses of Nonalcoholic Fatty Liver Disease.Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review.A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies.SUGP1 is a novel regulator of cholesterol metabolism.Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach.

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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

http://www.wikidata.org/entity/Q34213805

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2014 nî lūn-bûn

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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Nature Genetics

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Systematic evaluation of codin ...... and myocardial infarction risk

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Carl Platou

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Ellisiv B Mathiesen

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Gonçalo R Abecasis

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Håvard Dalen

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Ji Zhang

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Jifeng Zhang

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Jin Chen

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Oddgeir L Holmen

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Santhi K Ganesh

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Subramaniam Pennathur

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P2860

Genetic structure of Europeans: a view from the North-East

RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability

An integrated map of genetic variation from 1,092 human genomes

Finding the missing heritability of complex diseases

Heart Disease and Stroke Statistics--2013 Update: A Report From the American Heart Association

A map of human genome variation from population-scale sequencing

Biological, clinical and population relevance of 95 loci for blood lipids

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

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345-351

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10.1038/NG.2926

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4

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46

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Inger Njølstad

Cristen J. Willer

Daniel H Hovelson

Maja-Lisa Løchen

Ellen M Schmidt

Arnulf Langhammer

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2014-03-16T00:00:00Z

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260841676

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