A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.
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Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1HIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceVpu Protein: The Viroporin Encoded by HIV-1Viral Membrane Channels: Role and Function in the Virus Life CycleEvolutionary conflicts between viruses and restriction factors shape immunityIntrinsic cellular defenses against human immunodeficiency virusesCounteraction of the multifunctional restriction factor tetherinDifferential sensitivities of tetherin isoforms to counteraction by primate lentiviruses.Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir.Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu functionA Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.Simian-Human immunodeficiency viruses expressing chimeric subtype B/C Vpu proteins demonstrate the importance of the amino terminal and transmembrane domains in the rate of CD4(+) T cell loss in macaques.Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.Immunogenetics of small ruminant lentiviral infectionsRetromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.Vpu downmodulates two distinct targets, tetherin and gibbon ape leukemia virus envelope, through shared features in the Vpu cytoplasmic tail.Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.Vpu binds directly to tetherin and displaces it from nascent virions.Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation.Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasmaSerine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteins.Bacterial expression, correct membrane targeting and functional folding of the HIV-1 membrane protein Vpu using a periplasmic signal peptideThe size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release.TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse.A comparative mutational analysis of HIV-1 Vpu subtypes B and C for the identification of determinants required to counteract BST-2/Tetherin and enhance viral egress.Functional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions.HIV-1 Vpu - an ion channel in search of a job.Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates.Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread.Mechanisms underlying HIV-1 Vpu-mediated viral egress.Conserved residues within the HIV-1 Vpu transmembrane-proximal hinge region modulate BST2 binding and antagonism.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice.A Review of Functional Motifs Utilized by Viruses.Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses.
P2860
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P2860
A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@ast
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@en
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@nl
type
label
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@ast
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@en
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@nl
prefLabel
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@ast
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@en
A cytoplasmic tail determinant ...... nterferon-induced restriction.
@nl
P2860
P1433
P1476
A cytoplasmic tail determinant ...... interferon-induced restriction
@en
P2093
Tonya Kueck
P2860
P304
P356
10.1371/JOURNAL.PPAT.1002609
P50
P577
2012-03-29T00:00:00Z