Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.
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Opioid metabolismAbsorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol.Extended-release morphine sulfate in treatment of severe acute and chronic painLiver enzyme induction and inhibition: implications for anaesthesia.Cytochrome P450 2C8 pharmacogenetics: a review of clinical studiesPreclinical disposition (in vitro) of novel μ-opioid receptor selective antagonists.The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics.Regioselective biotransformation of CNS drugs and its clinical impact on adverse drug reactions.PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 8.The challenges of LC-MS/MS analysis of opiates and opioids in urine.Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Confirmation of recent heroin abuse: Accepting the challenge.Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo.Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions.The mineralocorticoid receptor antagonist spironolactone enhances morphine antinociception.The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.Toward reduction in animal sacrifice for drugs: molecular modeling of Macaca fascicularis P450 2C20 for virtual screening of Homo sapiens P450 2C8 substrates.Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling.
P2860
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P2860
Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@ast
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@en
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@nl
type
label
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@ast
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@en
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@nl
prefLabel
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@ast
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@en
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@nl
P2093
P2860
P1433
P1476
Identification of CYP3A4 and C ...... ion in human liver microsomes.
@en
P2093
P2860
P304
P356
10.1080/0049825031000121608
P407
P577
2003-08-01T00:00:00Z