Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.
about
Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect ProfileExploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor.In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel mu opioid analgesic with reduced propensity to alter motor functionSynthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies.Deconstructing 14-phenylpropyloxymetopon: minimal requirements for binding to mu opioid receptors.Most recent developments and modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan derivativesMolecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.Consensus 3D model of μ-opioid receptor ligand efficacy based on a quantitative Conformationally Sampled Pharmacophore.Insights into subtype selectivity of opioid agonists by ligand-based and structure-based methods.
P2860
Q27023246-E9855CDC-5607-44AB-AAF2-5E179CD9D4D4Q34001543-FA8C75B7-1BBD-49E5-86B8-F6148866D0F3Q34124185-0FD16A68-D530-4DBE-9F04-FE51E77F7D8CQ34583511-AD8C404E-FC77-4553-8D11-F6A5BC6FBCB3Q36107403-3CC1FCA4-240E-4484-81DA-29235A8F0708Q36107406-EB54ED05-C1D9-41E9-A624-ADD5ECE68984Q41061564-94552D02-BC9A-44CC-9EFD-ACBAEA56DBAEQ41835961-97DEA3AB-1F03-4029-BE66-7084E0BB7757Q44346651-24F6C690-AF12-4868-A691-A33232D60A01
P2860
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Synthesis and biological evalu ...... extremely powerful analgesic.
@ast
Synthesis and biological evalu ...... extremely powerful analgesic.
@en
Synthesis and biological evalu ...... extremely powerful analgesic.
@nl
type
label
Synthesis and biological evalu ...... extremely powerful analgesic.
@ast
Synthesis and biological evalu ...... extremely powerful analgesic.
@en
Synthesis and biological evalu ...... extremely powerful analgesic.
@nl
prefLabel
Synthesis and biological evalu ...... extremely powerful analgesic.
@ast
Synthesis and biological evalu ...... extremely powerful analgesic.
@en
Synthesis and biological evalu ...... extremely powerful analgesic.
@nl
P2093
P356
P1476
Synthesis and biological evalu ...... extremely powerful analgesic.
@en
P2093
Andrew Coop
Helmut Schmidhammer
Johannes Schütz
Louis S Harris
Mariana Spetea
Mario D Aceto
Martin Koch
P304
P356
10.1021/JM030878B
P407
P577
2003-09-01T00:00:00Z