Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells. - Wikidata - awgldk - TriplyDB

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.

http://www.wikidata.org/entity/Q34227609

about

Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.p73 regulates basal and starvation-induced liver metabolism in vivo.Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.Drug-induced amino acid deprivation as strategy for cancer therapy.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging.Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation.Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism.Glutamine Metabolism in Gliomas.Glutaminases.Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status.

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P2860

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.

http://www.wikidata.org/entity/Q34227609

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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type

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Discovery of selective inhibit ...... proliferation in cancer cells.

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ONCOTARGET.2173

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Discovery of selective inhibit ...... proliferation in cancer cells.

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Cheng-Wei Yang

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Chidambaram Ramesh Kumar

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Chih-Hao Lee

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Hsin-Yu Chang

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Hsing-Yu Hsu

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Hsun-Shuo Chang

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Ih-Shen Chen

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Jinq-chyi Lee

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Shiow-Ju Lee

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Ya-Qi Qiu

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P2860

Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase

Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Full-length human glutaminase in complex with an allosteric inhibitor

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

TSC2 mediates cellular energy response to control cell growth and survival

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

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