Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

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http://www.wikidata.org/entity/Q34244022

Q34244022

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Retinal Macroglial Responses in Health and Disease Diadenosine tetraphosphate as a potential therapeutic nucleotide to treat glaucoma.Glutathione induces GABA release through P2X7R activation on Müller glia.Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology.Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium Activated Müller Cells Involved in ATP-Induced Upregulation of P2X7 Receptor Expression and Retinal Ganglion Cell Death.A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of 2 and 4 Weeks of Twice-Daily Ocular Trabodenoson in Adults with Ocular Hypertension or Primary Open-Angle Glaucoma.In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications.Cross-sectional pupillographic evaluation of relative afferent pupillary defect in age-related macular degeneration.The properties, functions, and pathophysiology of maxi-anion channels.Principles of Ocular Pharmacology.Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury.The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain.A Randomized Phase 1 Dose Escalation Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Trabodenoson in Healthy Adult Volunteers Ocular Purine Receptors as Drug Targets in the Eye.Increased membrane localization of pannexin1 in human corneal synaptosomes causes enhanced stimulated ATP release in chronic diabetes mellitus.Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective.Purinergic Signalling: Therapeutic Developments.NTPDase2 and the P2Y1 receptor are not required for mammalian eye formation.Manipulation of Panx1 Activity Increases the Engraftment of Transplanted Lacrimal Gland Epithelial Progenitor Cells.The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina.The Adenosine Receptor Antagonist, 7-Methylxanthine, Alters Emmetropizing Responses in Infant Macaques.Novel therapeutics in glaucoma management.The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes.The P2X7 Receptor.Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.The two faces of pannexins: new roles in inflammation and repair.Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels.Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody Modulation of three key innate immune pathways for the most common retinal degenerative diseases Metabolomic changes in the mouse retina after optic nerve injury

P2860

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P2860

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

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http://www.wikidata.org/entity/Q34244022

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2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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