Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
about
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaquesOxygen Sensing and HomeostasisIn vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studiesHypoxia and fibrosis in chronic kidney disease: crossing at pericytesThe hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regenerationHIF hydroxylase pathways in cardiovascular physiology and medicineAttenuating myocardial ischemia by targeting A2B adenosine receptorsHIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epitheliumFrequently asked questions in hypoxia researchThe myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsWhole animal imaging.Molecular imaging agents: impact on diagnosis and therapeutics in oncologyIncreased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system.Real-time imaging of HIF-1alpha stabilization and degradation.Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway.Mechanisms of metabolic memory and renal hypoxia as a therapeutic target in diabetic kidney disease.Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.Regulation of 4E-BP1 activity in the mammalian oocyte.Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivoIn vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice.Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imagingAssessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter constructNoninvasive imaging of lipid nanoparticle-mediated systemic delivery of small-interfering RNA to the liver.Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.Drug-induced regeneration in adult mice.Dynamics of tumor hypoxia in response to patupilone and ionizing radiationOptical imaging in vivo with a focus on paediatric disease: technical progress, current preclinical and clinical applications and future perspectivesIntermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.Erythropoietin after a century of research: younger than ever.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis.Applications of molecular imaging.Molecular imaging in tumor angiogenesis and relevant drug researchLoss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.
P2860
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P2860
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mouse model for noninvasive im ...... ates erythropoietin production
@ast
Mouse model for noninvasive im ...... ates erythropoietin production
@en
Mouse model for noninvasive im ...... ates erythropoietin production
@nl
type
label
Mouse model for noninvasive im ...... ates erythropoietin production
@ast
Mouse model for noninvasive im ...... ates erythropoietin production
@en
Mouse model for noninvasive im ...... ates erythropoietin production
@nl
prefLabel
Mouse model for noninvasive im ...... ates erythropoietin production
@ast
Mouse model for noninvasive im ...... ates erythropoietin production
@en
Mouse model for noninvasive im ...... ates erythropoietin production
@nl
P2093
P2860
P356
P1476
Mouse model for noninvasive im ...... ates erythropoietin production
@en
P2093
Fionnuala O'Connell
James W Horner
Lee Flippin
Michal Safran
Ronald A Depinho
Volkmar Günzler
William Y Kim
P2860
P304
P356
10.1073/PNAS.0509459103
P407
P577
2005-12-22T00:00:00Z