Cyclin-dependent kinase 5 activity regulates pain signaling. - Wikidata - awgldk - TriplyDB

Cyclin-dependent kinase 5 activity regulates pain signaling.

Cyclin-dependent kinase 5 activity regulates pain signaling.

http://www.wikidata.org/entity/Q34249306

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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1 Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune respon Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.Cdk5 activity in the brain - multiple paths of regulation.Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats.Molecular Roles of Cdk5 in Pain Signaling Resveratrol inhibits Cdk5 activity through regulation of p35 expression Antiallodynic Effects of Electroacupuncture Combined with MK-801 Treatment through the Regulation of p35/p25 in Experimental Diabetic Neuropathy Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety.Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons.Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats.Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis.Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells.Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions.Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice What's the hype about CDK5RAP2?Cdk5: An Emerging Kinase in Pain Signaling Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats.Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats.[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.Modulation of TRPA1 channel activity by Cdk5 in Sensory neurons.Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.The transcription factor DeltaFosB is recruited by inflammatory pain.TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons.The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production.Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5.

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Cyclin-dependent kinase 5 activity regulates pain signaling.

http://www.wikidata.org/entity/Q34249306

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2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Cyclin-dependent kinase 5 activity regulates pain signaling.

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Cyclin-dependent kinase 5 activity regulates pain signaling.

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Cyclin-dependent kinase 5 activity regulates pain signaling.

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type

label

Cyclin-dependent kinase 5 activity regulates pain signaling.

@ast

Cyclin-dependent kinase 5 activity regulates pain signaling.

@en

Cyclin-dependent kinase 5 activity regulates pain signaling.

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prefLabel

Cyclin-dependent kinase 5 activity regulates pain signaling.

@ast

Cyclin-dependent kinase 5 activity regulates pain signaling.

@en

Cyclin-dependent kinase 5 activity regulates pain signaling.

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Proceedings of the National Academy of Sciences of the United States of America

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Cyclin-dependent kinase 5 activity regulates pain signaling

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Ashok B Kulkarni

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Harish C Pant

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Jason Keller

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Michael J Iadarola

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Roscoe O Brady

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Sashi Kesavapany

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The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner

Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems

Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1

Neurotoxicity induces cleavage of p35 to p25 by calpain

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats

Regulation of NMDA receptors by cyclin-dependent kinase-5

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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