Cyclin-dependent kinase 5 activity regulates pain signaling.
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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitisCyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune responMarked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.Cdk5 activity in the brain - multiple paths of regulation.Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats.Molecular Roles of Cdk5 in Pain SignalingResveratrol inhibits Cdk5 activity through regulation of p35 expressionAntiallodynic Effects of Electroacupuncture Combined with MK-801 Treatment through the Regulation of p35/p25 in Experimental Diabetic NeuropathyDeactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety.Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsTransforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons.Decreased Activity in Neuropathic Pain Form and Gene Expression of Cyclin-Dependent Kinase5 and Glycogen Synthase Kinase-3 Beta in Soleus Muscle of Wistar Male Rats.Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis.Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neuronsTGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells.Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions.Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in miceWhat's the hype about CDK5RAP2?Cdk5: An Emerging Kinase in Pain SignalingRegulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats.Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic painERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivityEstrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats.[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.Modulation of TRPA1 channel activity by Cdk5 in Sensory neurons.Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.The transcription factor DeltaFosB is recruited by inflammatory pain.TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons.The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production.Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5.
P2860
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P2860
Cyclin-dependent kinase 5 activity regulates pain signaling.
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Cyclin-dependent kinase 5 activity regulates pain signaling.
@ast
Cyclin-dependent kinase 5 activity regulates pain signaling.
@en
Cyclin-dependent kinase 5 activity regulates pain signaling.
@nl
type
label
Cyclin-dependent kinase 5 activity regulates pain signaling.
@ast
Cyclin-dependent kinase 5 activity regulates pain signaling.
@en
Cyclin-dependent kinase 5 activity regulates pain signaling.
@nl
prefLabel
Cyclin-dependent kinase 5 activity regulates pain signaling.
@ast
Cyclin-dependent kinase 5 activity regulates pain signaling.
@en
Cyclin-dependent kinase 5 activity regulates pain signaling.
@nl
P2093
P2860
P356
P1476
Cyclin-dependent kinase 5 activity regulates pain signaling
@en
P2093
Ashok B Kulkarni
Harish C Pant
Jason Keller
Michael J Iadarola
Roscoe O Brady
Sashi Kesavapany
P2860
P304
P356
10.1073/PNAS.0510405103
P407
P50
P577
2006-01-09T00:00:00Z