RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia - Wikidata - awgldk - TriplyDB

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

http://www.wikidata.org/entity/Q34249621

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Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models The Role of Arginine-Phenylalanine-Amide-Related Peptides in Mammalian Reproduction Contribution of GnIH Research to the Progress of Reproductive Neuroendocrinology Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents Induction of synaptic long-term potentiation after opioid withdrawal Proteomic analysis of PKCγ-related proteins in the spinal cord of morphine-tolerant rats Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus Endogenous opiates and behavior: 2006 The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance.Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis.Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands.Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.The Role of Neurotransmitters in Protection against Amyloid- β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons The hypothalamic neuropeptide FF network is impaired in hypertensive patients.Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.Exogenous and endogenous opioid-induced pain hypersensitivity in different rat strains.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives Review: neuroestrogen regulation of socio-sexual behavior of males Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.Kisspeptin prevention of amyloid-β peptide neurotoxicity in vitro.RF9 Acts as a KISS1R Agonist In Vivo and In Vitro.Assessment of morphine-induced hyperalgesia and analgesic tolerance in mice using thermal and mechanical nociceptive modalities.Nonpeptide ligands of neuropeptide FF: current status and structural insights.Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice Continuous opioid therapy (COT) is rarely advisable for refractory chronic daily headache: limited efficacy, risks, and proposed guidelines.Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.The hypothalamic NPVF circuit modulates ventral raphe activity during nociception.Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation.Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation.NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.

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RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

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2006 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Audrey Matifas

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Brigitte L Kieffer

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Jean-Paul Laulin

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P2860

Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor

Identification and characterization of two G protein-coupled receptors for neuropeptide FF

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226

Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process

Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine

Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library

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