Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein. - Wikidata - awgldk - TriplyDB

Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.

Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.

http://www.wikidata.org/entity/Q34264257

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Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate Early Events in Chikungunya Virus Infection-From Virus Cell Binding to Membrane Fusion DNA vaccine initiates replication of live attenuated chikungunya virus in vitro and elicits protective immune response in mice Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus Infectivity ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence A chikungunya fever vaccine utilizing an insect-specific virus platform Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies.Development of Vaccines for Chikungunya Fever.Next generation sequencing of DNA-launched Chikungunya vaccine virus.A small antigenic determinant of the Chikungunya virus E2 protein is sufficient to induce neutralizing antibodies which are partially protective in mice Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.A novel live-attenuated vaccine candidate for mayaro Fever.Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons.Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus.Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice.Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon Do we need a vaccine against chikungunya?New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.Chikungunya virus and prospects for a vaccine.Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus.A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus.Self-replicating alphavirus RNA vaccines.A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.Protective and Pathogenic Responses to Chikungunya Virus Infection.Chikungunya virus: recent advances in epidemiology, host pathogen interaction and vaccine strategies.How Chikungunya Virus Virology Affects Its Epidemiology and Transmission: Implications for Influencing Public Health.Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses.DNA-launched live-attenuated vaccines for biodefense applications.A fully attenuated recombinant Salmonid alphavirus becomes pathogenic through a single amino acid change in the E2 glycoprotein Protocols for Developing Novel Chikungunya Virus DNA Vaccines.Reverse Genetics Approaches for Chikungunya Virus.Recent progress on chikungunya virus research.Vaccine and Therapeutic Options To Control Chikungunya Virus.Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models.

P2860

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P2860

Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.

http://www.wikidata.org/entity/Q34264257

description

2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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Journal of Virology

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Attenuation of Chikungunya vir ...... the E2 envelope glycoprotein.

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P2093

A Paige Adams

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Charalambos D Partidos

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Erin M Borland

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Eryu Wang

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Grace Leal

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Kenneth Plante

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Michael B Sherman

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Naomi L Forrester

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Robert L Seymour

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Rodion Gorchakov

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P2860

Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak

Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism

A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease

Present and future arboviral threats

Chikungunya virus infection

Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling

Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation

An Amino Acid Substitution in the Coding Region of the E2 Glycoprotein Adapts Ross River Virus To Utilize Heparan Sulfate as an Attachment Moiety

Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice

Attenuation of Venezuelan equine encephalitis virus strain TC-83 is encoded by the 5'-noncoding region and the E2 envelope glycoprotein

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6084-6096

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scholarly article

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10.1128/JVI.06449-11

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P433

11

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86

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Scott C. Weaver

Jorge E. Osorio

James Weger-Lucarelli

Shannan L Rossi

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2012-03-28T00:00:00Z

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223137227

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22457519

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Chikungunya virus

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3372191

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