Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.
about
A human-curated annotation of the Candida albicans genome.Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomesPredicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive ReviewFungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local eventsValidation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious diseaseDe novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformansRecent advances on Candida albicans biology and virulencePrioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosisEssential gene identification and drug target prioritization in Aspergillus fumigatusGenome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicansGene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collectionSystematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genesRechecking the Centrality-Lethality Rule in the Scope of Protein Subcellular Localization Interaction NetworksMapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular StressA New Method for Identifying Essential Proteins Based on Network Topology Properties and Protein ComplexesMetal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and MorphogenesisSelective BET bromodomain inhibition as an antifungal therapeutic strategyForward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.Conserved fungal genes as potential targets for broad-spectrum antifungal drug discovery.Towards the identification of essential genes using targeted genome sequencing and comparative analysis.Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information.Evolutionary tinkering with conserved components of a transcriptional regulatory network.Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.CEG: a database of essential gene clusters.The transposon impala is activated by low temperatures: use of a controlled transposition system to identify genes critical for viability of Aspergillus fumigatusMolecular genetic techniques for gene manipulation in Candida albicans.Comparative genomics allowed the identification of drug targets against human fungal pathogens.Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesisStrains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicansGenetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan.Functional genomic analysis of the rates of protein evolution.Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategyTraining set selection for the prediction of essential genesRole of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyeneAn Approach for Predicting Essential Genes Using Multiple Homology Mapping and Machine Learning Algorithms.Compound prioritization methods increase rates of chemical probe discovery in model organisms.Antifungal drug discovery: the process and outcomes.A new essential protein discovery method based on the integration of protein-protein interaction and gene expression data.
P2860
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P2860
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Large-scale essential gene ide ...... to antifungal drug discovery.
@ast
Large-scale essential gene ide ...... to antifungal drug discovery.
@en
Large-scale essential gene ide ...... to antifungal drug discovery.
@nl
type
label
Large-scale essential gene ide ...... to antifungal drug discovery.
@ast
Large-scale essential gene ide ...... to antifungal drug discovery.
@en
Large-scale essential gene ide ...... to antifungal drug discovery.
@nl
prefLabel
Large-scale essential gene ide ...... to antifungal drug discovery.
@ast
Large-scale essential gene ide ...... to antifungal drug discovery.
@en
Large-scale essential gene ide ...... to antifungal drug discovery.
@nl
P2093
P2860
P1476
Large-scale essential gene ide ...... to antifungal drug discovery.
@en
P2093
Annie Linteau
Anouk Breton
Catarina Marta
Charles Boone
Fatou Tandia
Howard Bussey
Jeff Becker
John Davison
Karynn Veillette
P2860
P304
P356
10.1046/J.1365-2958.2003.03697.X
P407
P577
2003-10-01T00:00:00Z