Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. - Wikidata - awgldk - TriplyDB

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

http://www.wikidata.org/entity/Q34270135

about

Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Transcriptional and epigenetic regulation of autophagy in aging Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients Spinal and Bulbar Muscular Atrophy.Mitophagy: therapeutic potentials for liver disease and beyond.Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells.Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy.Lysosomal adaptation: How cells respond to lysosomotropic compounds.TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases.Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective Spinal and Bulbar Muscular Atrophy Overview.Autophagic activity in neuronal cell death The Role of the Protein Quality Control System in SBMA.Targeted Molecular Therapies for SBMA.In Vitro and In Vivo Modeling of Spinal and Bulbar Muscular Atrophy.Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Androgen receptor-related diseases: what do we know?Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains.Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain.Phospholipid arrays on porous polymer coatings generated by micro-contact spotting.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.CLEARance wars: PolyQ strikes back.Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins.The serine 106 residue within the N-terminal transactivation domain is crucial for Oct4 function in mice.Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System.Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model.Association Between Autophagy and Neurodegenerative Diseases.TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

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P2860

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

http://www.wikidata.org/entity/Q34270135

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

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name

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@ast

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@en

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

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type

label

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@ast

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@en

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@nl

prefLabel

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@ast

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@en

Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

@nl

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Polyglutamine-expanded androge ...... cit autophagy defects in SBMA.

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Albert R La Spada

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Alysson R Muotri

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Amy Le

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Bryce L Sopher

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Constanza J Cortes

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Harald Frankowski

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Helen C Miranda

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Nishi Ivanov

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Yakup Batlevi

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

A gene network regulating lysosomal biogenesis and function

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Cellular and molecular mechanisms of muscle atrophy

Autophagy in the Pathogenesis of Disease

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Sumoylation of MITF and its related family members TFE3 and TFEB

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Cassiano Carromeu

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2014-08-10T00:00:00Z

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