p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis - Wikidata - awgldk - TriplyDB

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis

http://www.wikidata.org/entity/Q34273826

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FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells Oncogenic Intra-p53 Family Member Interactions in Human Cancers Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.ΔNp63 isoform-mediated β-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells p53/p63/p73 in the epidermis in health and disease DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.p53 Family and Cellular Stress Responses in Cancer.The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells.IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues.ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients.p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function.The function of Drosophila p53 isoforms in apoptosis.The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth Human papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53.ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis Fully interlocking: a story of teamwork among breast epithelial cells.BamHI-A rightward frame 1, an Epstein-Barr virus-encoded oncogene and immune modulator.MicroRNAs and p63 in epithelial stemness.Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression.ΔNp63α attenuates tumor aggressiveness by suppressing miR-205/ZEB1-mediated epithelial-mesenchymal transition in cervical squamous cell carcinoma.Maintaining epithelial stemness with p63.Genetic landscape and deregulated pathways in B-cell lymphoid malignancies.The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy.Decreased TAp63 and ΔNp63 mRNA Levels in Most Human Pituitary Adenomas Are Correlated with Notch3/Jagged1 Relative Expression.Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.Functions of TAp63 and p53 in restraining the development of metastatic cancer.New Insights in Thyroid Cancer and p53 Family Proteins.Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.Exploiting poly(I:C) to induce cancer cell apoptosis.Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.The family that eats together stays together: new p53 family transcriptional targets in autophagy.

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p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis

http://www.wikidata.org/entity/Q34273826

description

2013 nî lūn-bûn

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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

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Nature Reviews Cancer

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p63 steps into the limelight: ...... f tumorigenesis and metastasis

@en

P2093

Deepavali Chakravarti

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Elsa R Flores

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Xiaohua Su

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P2860

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

The ubiquitin-protein ligase Itch regulates p73 stability

Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation

Binding and modulation of p53 by p300/CBP coactivators

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

A new human p53 homologue

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

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10.1038/NRC3446

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