Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature
about
New insights into the pathogenesis and therapeutics of episodic ataxia type 1K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy.A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxiaLack of neuropathy-related phenotypes in hint1 knockout mice.Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.Novel phenotype associated with a mutation in the KCNA1(Kv1.1) geneThe episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels.Mutational consequences of aberrant ion channels in neurological disorders.Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits.
P2860
Q26782897-71A9B064-2D21-44EE-A8A5-8A8D22B1F518Q30449041-A342F478-AC06-4AF6-BDB7-E39011997369Q33870521-1D61DDD7-6AA5-4529-8375-182A9E13D8AAQ33901811-CA65371E-7977-4D81-9276-15B09B16600DQ34390785-8F963A20-9BE9-40F5-919D-AF2CCA7A73CEQ34969098-D62D7DD1-D520-4FB7-AA6F-9D969DB96C87Q36500042-EEF438A3-11AD-4ACC-A195-29B81F5ACED7Q38239544-42D4830D-F78F-46DE-8F12-AF8E294D7796Q40443495-548BE004-788A-494E-A4C8-56BB1E812F71Q44425941-88FCF107-9E52-47D8-A08C-AB56D9A7C1C1
P2860
Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@ast
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@en
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@nl
type
label
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@ast
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@en
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@nl
prefLabel
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@ast
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@en
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@nl
P2093
P2860
P1476
Kv1.1 knock-in ataxic mice exh ...... , ischemia and low temperature
@en
P2093
Christian Zammit
Fabio Massimo Botti
Maria Cristina D'Adamo
Marina Mora
Mario Valentino
Mauro Pessia
Orazio Brunetti
Paola Imbrici
Richard Muscat
Sara Gibertini
P2860
P304
P356
10.1016/J.NBD.2012.05.002
P577
2012-05-17T00:00:00Z