Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. - Wikidata - awgldk - TriplyDB

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

http://www.wikidata.org/entity/Q34285505

about

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology Intracellular Mono-ADP-Ribosylation in Signaling and Disease Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming SIRTain regulators of premature senescence and accelerated aging Redox regulation of SIRT1 in inflammation and cellular senescence Aging and radiation: bad companions Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations Increased mammogram-induced DNA damage in mammary epithelial cells aged in vitro Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum Minimally invasive bipolar fractional radiofrequency treatment upregulates anti-senescence pathways.SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.Do DNA Double-Strand Breaks Drive Aging?Sirtuins and DNA damage repair: SIRT7 comes to play.Sorting out functions of sirtuins in cancer Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes.SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC.Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome Protective effects of sirtuins in cardiovascular diseases: from bench to bedside In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage.Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population.Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells.DNA double strand break repair, aging and the chromatin connection.Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6 The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence.SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation.Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells.Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders Sirtuins in stress response: guardians of the genome.The diversity of histone versus nonhistone sirtuin substrates.Senescent cells: SASPected drivers of age-related pathologies.Accelerated ageing of the lung in COPD: new concepts.Low- and High-LET Ionizing Radiation Induces Delayed Homologous Recombination that Persists for Two Weeks before Resolving.Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans.Sirtuins, a promising target in slowing down the ageing process.

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P2860

Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

http://www.wikidata.org/entity/Q34285505

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

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Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

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Sirtuin 6

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Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

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Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

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Sirtuin 6

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Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

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Sirtuin 6

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P1433

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PNAS.1200583109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Sirtuin 6 (SIRT6) rescues the ...... during replicative senescence.

@en

P2093

Andrei Seluanov

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Michael Van Meter

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Vera Gorbunova

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Zhiyong Mao

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Zhonghe Ke

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P2860

Human SIRT6 promotes DNA end resection through CtIP deacetylation

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing

Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Human CtIP promotes DNA end resection

Effects of age on DNA double-strand breaks and apoptosis in human sperm

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11800-11805

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29

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109

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228105287

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22753495

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3406824

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