Development of anticancer drugs targeting the MAP kinase pathway.
about
Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxelSmall-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonistsOver-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosisDemonstration of mixed properties of RU486 in progesterone receptor (PR)-transfected MDA-MB-231 cells: a model for studying the functions of progesterone analoguesInvestigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysisFucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathwaysThe Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) PathwayRibosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.Metaplastic breast cancer: histologic characteristics, prognostic factors and systemic treatment strategies.p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Real time visualization of protein kinase activity in living cells.Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status.Selection and separation of viable cells based on a cell-lethal assay.Phosphorylation of the transcription factor Ets-1 by ERK2: rapid dissociation of ADP and phospho-Ets-1.A screen to identify cellular modulators of soluble levels of an amyotrophic lateral sclerosis (ALS)-causing mutant SOD1.GnRH signaling, the gonadotrope and endocrine control of fertility.Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells.Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.Distinct requirements for Ras oncogenesis in human versus mouse cells.The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.The apoptotic effect of D Rhamnose β-hederin, a novel oleanane-type triterpenoid saponin on breast cancer cells.Review article: mitogen-activated protein kinases in chronic intestinal inflammation - targeting ancient pathways to treat modern diseases.Pathobiology and chemoprevention of bladder cancerActivation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathwayCurcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells.Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis.Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.Induction of cancer cell death by isoflavone: the role of multiple signaling pathways.Therapeutic modulation of signal transduction pathways.Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation.Cancer therapeutics: understanding the mechanism of action.Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer.Molecular pathways in bladder cancer: part 1.Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.RSK2 as a key regulator in human skin cancer.Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
P2860
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P2860
Development of anticancer drugs targeting the MAP kinase pathway.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Development of anticancer drugs targeting the MAP kinase pathway.
@ast
Development of anticancer drugs targeting the MAP kinase pathway.
@en
Development of anticancer drugs targeting the MAP kinase pathway.
@nl
type
label
Development of anticancer drugs targeting the MAP kinase pathway.
@ast
Development of anticancer drugs targeting the MAP kinase pathway.
@en
Development of anticancer drugs targeting the MAP kinase pathway.
@nl
prefLabel
Development of anticancer drugs targeting the MAP kinase pathway.
@ast
Development of anticancer drugs targeting the MAP kinase pathway.
@en
Development of anticancer drugs targeting the MAP kinase pathway.
@nl
P2860
P356
P1433
P1476
Development of anticancer drugs targeting the MAP kinase pathway.
@en
P2093
J S Sebolt-Leopold
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204083
P407
P577
2000-12-01T00:00:00Z
P5875
P6179
1044594511