Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.
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Cloning and expression of human deoxyguanosine kinase cDNACloning and expression of human mitochondrial deoxyguanosine kinase cDNAStructures of thymidine kinase 1 of human and mycoplasmic originNucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallographyThe effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinaseCrystal structure of varicella zoster virus thymidine kinaseCrystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATPExploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligandsStructure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovirFunctional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutantsBiochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cellsCloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoformA mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant.Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and Ganglia.An Escherichia coli system expressing human deoxyribonucleoside salvage enzymes for evaluation of potential antiproliferative nucleoside analogs.Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties.The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: a new strategy?Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementLow-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase.Thermodynamics of protein-ligand interactions: history, presence, and future aspects.Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal gangliaDevelopment of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.3'-Amino thymidine affinity matrix for the purification of herpes simplex virus thymidine kinase.Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography.Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair.Synthesis, molecular conformation and activity against herpes simplex virus of (E)-5-(2-bromovinyl)-2'-deoxycytidine analogs.Novel 1,2,4-triazole and purine acyclic cyclopropane nucleoside analogues: synthesis, antiviral and cytostatic activity evaluations.Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK.Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.Replication fidelity of the supF gene integrated in the thymidine kinase locus of herpes simplex virus type 1.Mutation spectra of herpes simplex virus type 1 thymidine kinase mutantsCytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging.Identification and characterization of the conserved nucleoside-binding sites in the Epstein-Barr virus thymidine kinase.Antiherpesvirus activities of two novel 4'-thiothymidine derivatives, KAY-2-41 and KAH-39-149, are dependent on viral and cellular thymidine kinases.The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogueIntracellular localization of Herpes simplex virus type 1 thymidine kinase fused to different fluorescent proteins depends on choice of fluorescent tag.The rational of catalytic activity of herpes simplex virus thymidine kinase. a combined biochemical and quantum chemical study.
P2860
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P2860
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@ast
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@en
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@nl
type
label
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@ast
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@en
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@nl
prefLabel
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@ast
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@en
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@nl
P2093
P2860
P356
P1476
Crystal structures of the thym ...... eoxythymidine and ganciclovir.
@en
P2093
Rizkallah PJ
Sanderson MR
Summers WC
P2860
P304
P356
10.1038/NSB1095-876
P577
1995-10-01T00:00:00Z