Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.
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The secretory phospholipase A2 group IIA: a missing link between inflammation, activated renin-angiotensin system, and atherogenesis?Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionBioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines.Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase.Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glandsGroup X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.Friend Turns Foe: Transformation of Anti-Inflammatory HDL to Proinflammatory HDL during Acute-Phase ResponseEctopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesisGroup V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.Role of sphingomyelin and ceramide in the regulation of the activity and fatty acid specificity of group V secretory phospholipase A2.A new era of secreted phospholipase A₂Impact of atorvastatin treatment on platelet-activating factor acetylhydrolase and 15-F(2trans)-isoprostane in hypercholesterolaemic patients.High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation.Secretory PLA2 inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFalpha-stimulated human endothelial cells.Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL.Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice.Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery diseaseThe capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Secreted phospholipase A2, lipoprotein hydrolysis, and atherosclerosis: integration with lipidomicsMolecular biology of atherosclerosis.Pioglitazone suppresses the lipopolysaccharide-induced production of inflammatory factors in mouse macrophages by inactivating NF-kappaB.PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS.The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.Decrease in pH strongly enhances binding of native, proteolyzed, lipolyzed, and oxidized low density lipoprotein particles to human aortic proteoglycans.The dual role of group V secretory phospholipase A2 in pancreatic β-cells.Diverse Functions of Secretory Phospholipases A2
P2860
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P2860
Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@ast
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@en
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@nl
type
label
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@ast
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@en
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@nl
prefLabel
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@ast
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@en
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@nl
P2093
P921
P1476
Group V sPLA2 hydrolysis of lo ...... acrophage foam cell formation.
@en
P2093
Boris B Boyanovsky
C Ruth Wooton-Kee
Munira S Nasser
Nancy R Webb
Willem J S de Villiers
P304
P356
10.1161/01.ATV.0000122363.02961.C1
P407
P577
2004-02-12T00:00:00Z